2-Acetyl-8-methoxy-3-(4-methoxyphenyl)-3,3A,4,5-tetrahydro-2H-benzo(G)indazole

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 2-Acetyl-8-methoxy-3-(4-methoxyphenyl)-3,3A,4,5-tetrahydro-2H-benzo(G)indazole
• 英文别名: 1-[8-methoxy-3-(4-methoxyphenyl)-3,3a,4,5-tetrahydrobenzo[g]indazol-2-yl]ethanone
• 化学式: C₂₁H₂₂N₂O₃
• mdl: MFCD00558666
• 分子量: 350.4
• InChiKey: QXGBVUBUQAGSCW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  51.1
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Compounds, Screens, and Methods of Treatment
  申请人：Yuan Junying

  公开号：US20100190836A1

  公开（公告）日：2010-07-29

  The present invention features compounds, pharmaceutical compositions, and methods for treating trauma, ischemia, stroke, degenerative diseases associated with cellular necrosis, and other conditions. Screening assays for identifying compounds useful for treating these conditions are also described.

  本发明涉及化合物、药物组合物和治疗创伤、缺血、中风、与细胞坏死相关的退行性疾病以及其他疾病的方法。还描述了用于识别治疗这些疾病的化合物的筛选测定方法。
• Methods for treating spinal cord injury
  申请人：Massachusetts Eye and Ear Infirmary

  公开号：US10022419B2

  公开（公告）日：2018-07-17

  Provided are methods for promoting axon regeneration of a Central Nervous System (CNS) neuron and promoting nerve function following injury to a CNS neuron, for example, brain and/or spinal cord injury. Axon regeneration in a CNS neuron or nerve function following injury to a CNS neuron can be promoted by administering a necrosis inhibitor either alone or in combination with an apoptosis inhibitor to a subject suffering from a CNS disorder, wherein a symptom of the CNS disorder is axon degeneration.

  本文提供了促进中枢神经系统（CNS）神经元轴突再生和促进中枢神经系统神经元损伤后神经功能的方法，例如脑和/或脊髓损伤。中枢神经系统神经元的轴突再生或中枢神经系统神经元损伤后的神经功能可通过向患有中枢神经系统疾病的受试者单独施用坏死抑制剂或与凋亡抑制剂联合施用来促进，其中中枢神经系统疾病的症状是轴突变性。
• Methods and compositions for preserving retinal ganglion cells
  申请人：Massachusetts Eye and Ear Infirmary

  公开号：US10617735B2

  公开（公告）日：2020-04-14

  Provided are methods and compositions for maintaining the viability of retinal ganglion cells in a subject with an ocular disorder including, for example, glaucoma and optic nerve injury. The viability of the retinal ganglion cells can be preserved by administering a necrosis inhibitor either alone or in combination with an apoptosis inhibitor to a subject having an eye with the ocular condition. The compositions, when administered, maintain the viability of the cells and/or promote axon regeneration, thereby minimizing the loss of vision or visual function associated with the ocular disorder.

  本发明提供了维持患有眼部疾病（例如青光眼和视神经损伤）的患者视网膜神经节细胞活力的方法和组合物。通过向患有眼部疾病的患者单独施用坏死抑制剂或与凋亡抑制剂联合施用，可保持视网膜神经节细胞的活力。给药后，组合物可维持细胞的活力和/或促进轴突再生，从而最大程度地减少与眼部疾病相关的视力或视觉功能的丧失。
• Compositions for preserving photoreceptor cells, retinal pigment epithelial cells, or visual function
  申请人：Massachusetts Eye and Ear Infirmary

  公开号：US10639345B2

  公开（公告）日：2020-05-05

  Provided are methods and compositions for maintaining the viability of photoreceptor cells and/or retinal pigment epithelial cells in a subject with an ocular disorder including, for example, age-related macular degeneration (AMD) (e.g., dry or neovascular AMD), retinitis pigmentosa (RP), or a retinal detachment. The viability of the photoreceptor cells and/or the retinal pigment epithelial cells can be preserved by administering a necrosis inhibitor either alone or in combination with an apoptosis inhibitor to a subject having an eye with the ocular condition. The compositions, when administered, maintain the viability of the cells, thereby minimizing the loss of vision or visual function associated with the ocular disorder.

  本发明提供的方法和组合物用于维持患有眼部疾病（例如老年性黄斑变性（AMD）（如干性或新生血管性AMD）、视网膜色素变性（RP）或视网膜脱离）的受试者的感光细胞和/或视网膜色素上皮细胞的活力。对患有眼部疾病的患者单独施用坏死抑制剂或与凋亡抑制剂联合施用，可保持感光细胞和/或视网膜色素上皮细胞的活力。这些组合物在给药后可保持细胞的活力，从而最大程度地减少与眼部疾病相关的视力或视觉功能的丧失。
• Methods for treating diabetic neurotherapy
  申请人：Massachusetts Eye and Ear Infirmary

  公开号：US10799552B2

  公开（公告）日：2020-10-13

  Provided are methods for promoting axon regeneration of a Central Nervous System (CNS) neuron and promoting nerve function following injury to a CNS neuron, for example, brain and/or spinal cord injury. Axon regeneration in a CNS neuron or nerve function following injury to a CNS neuron can be promoted by administering a necrosis inhibitor either alone or in combination with an apoptosis inhibitor to a subject suffering from a CNS disorder, wherein a symptom of the CNS disorder is axon degeneration.

  本文提供了促进中枢神经系统（CNS）神经元轴突再生和促进中枢神经系统神经元损伤后神经功能的方法，例如脑和/或脊髓损伤。中枢神经系统神经元的轴突再生或中枢神经系统神经元损伤后的神经功能可通过向患有中枢神经系统疾病的受试者单独施用坏死抑制剂或与凋亡抑制剂联合施用来促进，其中中枢神经系统疾病的症状是轴突变性。