15-Benzyl-14-ethyl-18-(4-methylphenyl)-11-oxa-13,15-diazatetracyclo[8.8.0.02,7.012,17]octadeca-1(10),2,4,6,8,12(17),13-heptaen-16-one | 1258277-87-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: 15-Benzyl-14-ethyl-18-(4-methylphenyl)-11-oxa-13,15-diazatetracyclo[8.8.0.02,7.012,17]octadeca-1(10),2,4,6,8,12(17),13-heptaen-16-one
• CAS: 1258277-87-0
• 化学式: C₃₁H₂₆N₂O₂
• 分子量: 458.56
• InChiKey: BAGBHKOCPODUBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  35
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  41.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-[(ethoxypropylidene)amino]-2-ethoxycarbonyl-1-(p-methylphenyl)-1H-naphtho-[2,1-b]pyran 、 苄胺 以 甲苯 为溶剂， 反应 48.0h， 以45%的产率得到15-Benzyl-14-ethyl-18-(4-methylphenyl)-11-oxa-13,15-diazatetracyclo[8.8.0.02,7.012,17]octadeca-1(10),2,4,6,8,12(17),13-heptaen-16-one
  参考文献：
  名称：

  Convenient Synthesis of 11-Aryl-1,12-dihydro-11H-naphthopyrano[2,3-d]pyrimidin-12-ones

  摘要：

  Various imidates 3 were successfully synthesized from naphthopyrans and ethyl orthoesters in moderate yields. These intermediates undergo rapid condensation with several primary amines to give the corresponding 11-aryl-1,12-dihydro-11H-naphthopyrano[2,3-d] pyrimidin-12-ones 4.

  DOI：

  10.1080/00397910903419928

文献信息

• Convenient Synthesis of 11-Aryl-1,12-dihydro-11<i>H</i>-naphthopyrano[2,3-d]pyrimidin-12-ones
  作者：Kamar Mkaouar、Fakher Chabchoub、Abdelouahid Samadi、José Louis Marco Contelles、Mansour Salem

  DOI：10.1080/00397910903419928

  日期：2010.10.20

  Various imidates 3 were successfully synthesized from naphthopyrans and ethyl orthoesters in moderate yields. These intermediates undergo rapid condensation with several primary amines to give the corresponding 11-aryl-1,12-dihydro-11H-naphthopyrano[2,3-d] pyrimidin-12-ones 4.