7-[3-(dimethylamino)propylamino]-2-methyl-14H-naphtho[3,2-a]phenoxazine-8,13-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 7-[3-(dimethylamino)propylamino]-2-methyl-14H-naphtho[3,2-a]phenoxazine-8,13-dione
• 化学式: C₂₆H₂₅N₃O₃
• 分子量: 427.5
• InChiKey: KSDYVAMLNDHYDI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  70.7
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS
  申请人：Reed John C.

  公开号：US20090118135A1

  公开（公告）日：2009-05-07

  An assay for determining compounds that inhibit activity of a BCl-2 protein, or affect conversion of Bcl-2 from an antiapoptotic to a proapoptotic form are described. In addition, compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and related Bcl-2 family members are identified.