3,3-Dimethylbutan-2-yl 4-(3-bromo-4-hydroxy-5-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 3,3-Dimethylbutan-2-yl 4-(3-bromo-4-hydroxy-5-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
• 英文别名: 3,3-dimethylbutan-2-yl 4-(3-bromo-4-hydroxy-5-methoxyphenyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
• 化学式: C₁₉H₂₅BrN₂O₅
• 分子量: 441.3
• InChiKey: BAOKMQXGGXJCFB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  96.9
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• [EN] COMPOUNDS, COMPOSITIONS, AND METHODS<br/>[FR] COMPOSES, COMPOSITIONS ET METHODES
  申请人：CYTOKINETICS INC

  公开号：WO2005037799A1

  公开（公告）日：2005-04-28

  Compounds useful for treating cellular proliferative diseases are disclosed.

  用于治疗细胞增殖性疾病的化合物已被披露。
• Cellular phenotype
  申请人：Adams Lynn Cynthia

  公开号：US20050282208A1

  公开（公告）日：2005-12-22

  Phenotypes and the cells that exhibit those phenotypes are described. The phenotype may be established as a “snapshot” of the cells at a particular time or it may be established as a variation in features over time, or as some combination of these “static” and “dynamic” characterizations. The phenotype may be characterized by at least the following features: (a) chromosomes that approach metaphase but fail to separate and maintain alignment compared to a control cell or cell population; (b) a bipolar spindle that is at least about 10% longer than a corresponding metaphase mitotic spindle from the control cell or cell population; and (c) during interphase the cell or population of cells exhibits a phenotype that is substantially similar to that of the interphase cells of the control cell or cell population.

  表型和表现出这些表型的细胞被描述出来。表型可以是细胞在特定时间的 "快照"，也可以是随时间变化的特征，或者是这些 "静态 "和 "动态 "特征的组合。表型至少具有以下特征：(a) 与对照细胞或细胞群相比，染色体接近分裂期但未能分离并保持排列整齐；(b) 双极纺锤体比对照细胞或细胞群的相应分裂期有丝分裂纺锤体至少长约 10%；以及 (c) 在间期，细胞或细胞群表现出与对照细胞或细胞群的间期细胞基本相似的表型。
• Compounds, compositions, and methods
  申请人：Ramchandani Shyamlal

  公开号：US20050282838A1

  公开（公告）日：2005-12-22

  Compounds useful for treating cellular proliferative diseases are disclosed.

  本研究公开了可用于治疗细胞增殖性疾病的化合物。
• COMPOUNDS, COMPOSITIONS, AND METHODS
  申请人：Cytokinetics, Inc.

  公开号：EP1675834A1

  公开（公告）日：2006-07-05
• EP1675834A4
  申请人：——

  公开号：EP1675834A4

  公开（公告）日：2008-08-27