2,6-Dimethyl-4-((E)-2-pyridin-2-yl-vinyl)-phenol | 127063-64-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2,6-Dimethyl-4-((E)-2-pyridin-2-yl-vinyl)-phenol
• 英文别名: 2,6-dimethyl-4-[(E)-2-pyridin-2-ylethenyl]phenol
• CAS: 127063-64-3
• 化学式: C₁₅H₁₅NO
• 分子量: 225.29
• InChiKey: FDAUKGHWWDPCEV-VOTSOKGWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  33.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3,5-二甲基-4-羟基苯甲醛 生成 2,6-Dimethyl-4-((E)-2-pyridin-2-yl-vinyl)-phenol
  参考文献：
  名称：

  LAZER, EDWARD S.;WONG, HIN-CHOR;WEGNER, GRAIG D.;GRAHAM, ANNE G.;FARINA, +, J. MED. CHEM., 33,(1990) N, C. 1892-1898

  摘要：

  DOI：

文献信息

• Thermosettable compounds prepared from monohydroxy aromatic aldehydes and methylated pyridines or pyrazines
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0212095A1

  公开（公告）日：1987-03-04

  Thermostable compounds are prepared by reac­ting methylated pyridines and/or pyrazines with one or more monohydroxy aromatic aldehydes having the ortho and para positions to the hydroxy group block with groups inert to condensation reactions. These com­pounds are useful to make unsaturated derivatives which can cure into high temperature resistant polymers and/or laminates without giving off condensation products.

  将甲基化的吡啶和/或吡嗪与一种或多种单羟基芳香醛反应，制备耐热化合物。这些化合物用于制造不饱和衍生物，可以固化成耐高温聚合物和/或层压板，而不会产生缩合产物。
• Effect of structure on potency and selectivity in 2,6-disubstituted-4-(2-arylethenyl)phenol lipoxygenase inhibitors
  作者：Edward S. Lazer、Hin Chor Wong、Craig D. Wegner、Anne G. Graham、Peter R. Farina

  DOI：10.1021/jm00169a010

  日期：1990.7

  A series of 2,6-disubstituted 4-(2-arylethenyl)phenols with potent human neutrophil 5-lipoxygenase (5-LO) inhibiting activity (IC50S in the 10(-7) M range) and weaker human platelet cyclooxygenase (CO) inhibiting activity (IC50S in the 10(-6) M range) is described. This series evolved from the chemical modification of an antiinflammatory dual CO/5-LO inhibitor, 2,6-di-tert-butyl-4-[2-(3-pyridyl)ethenyl]phenol (BI-L-93 BS). The potency and selectivity for 5-LO inhibition is greatly influenced by the nature of the substituents in the 2- and 6-positions. Other structure-activity relationships that determine relative 5-LO and CO potency are discussed. In vivo activity against antigen-induced leukotriene-mediated bronchoconstriction and cell influx in guinea pigs is presented. Representatives of the series are active when administered at 30 mg/kg ip.
• US4600767A
  申请人：——

  公开号：US4600767A

  公开（公告）日：1986-07-15