4-(1-naphthyl)-2-methoxyphenol | 899827-12-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-(1-naphthyl)-2-methoxyphenol
• 英文别名: p-(naphthyl-2-methoxy)phenol；2-Methoxy-4-(naphthalen-1-yl)phenol；2-methoxy-4-naphthalen-1-ylphenol
• CAS: 899827-12-4
• 化学式: C₁₇H₁₄O₂
• 分子量: 250.297
• InChiKey: AWBITUJXWFXJBR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-溴邻甲氧基苯酚 、 1-萘硼酸 在 palladium on activated charcoal 氢氧化钾 作用下， 以 水 为溶剂， 反应 0.25h， 以58%的产率得到4-(1-naphthyl)-2-methoxyphenol
  参考文献：
  名称：

  An expeditious aqueous Suzuki–Miyaura method for the arylation of bromophenols

  摘要：

  The development of a novel Suzuki-Miyaura method has been achieved to allow the efficient arylation of bromophenols. A range of functionality is tolerated with,regard to the boronic acid coupling partner and the reaction exhibits complete chemoselectivity for the C-aryl-Br bond versus the C-aryl-Cl bond in the aryl halide input. The experimental protocol features a short reaction time of 15 min, utilizes inexpensive Pd/C as a catalyst, and is conducted with water as the solvent. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.04.027

文献信息

• US4590301A
  申请人：——

  公开号：US4590301A

  公开（公告）日：1986-05-20
• An expeditious aqueous Suzuki–Miyaura method for the arylation of bromophenols
  作者：Joel S. Freundlich、Howard E. Landis

  DOI：10.1016/j.tetlet.2006.04.027

  日期：2006.6

  The development of a novel Suzuki-Miyaura method has been achieved to allow the efficient arylation of bromophenols. A range of functionality is tolerated with,regard to the boronic acid coupling partner and the reaction exhibits complete chemoselectivity for the C-aryl-Br bond versus the C-aryl-Cl bond in the aryl halide input. The experimental protocol features a short reaction time of 15 min, utilizes inexpensive Pd/C as a catalyst, and is conducted with water as the solvent. (c) 2006 Elsevier Ltd. All rights reserved.