1-N-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-4-N,4-N-dimethylbenzene-1,4-diamine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-N-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-4-N,4-N-dimethylbenzene-1,4-diamine
• 化学式: C₁₇H₁₆ClN₃S
• 分子量: 329.8
• InChiKey: BKEJEQZVKWLBQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  56.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] COMPOSITIONS FOR TREATING AND/OR PREVENTING CELL OR TISSUE NECROSIS SPECIFICALLY TARGETING CATHEPSIN C AND/OR CELA1 AND/OR CELA3A AND/OR STRUCTURALLY RELATED ENZYMES THERETO<br/>[FR] COMPOSITIONS DE TRAITEMENT ET/OU DE PRÉVENTION DE LA NÉCROSE TISSULAIRE OU CELLULAIRE CIBLANT SPÉCIFIQUEMENT LA CATHEPSINE C ET/OU CELA1 ET/OU CELA3A ET/OU DES ENZYMES Y ÉTANT STRUCTURELLEMENT APPARENTÉES
  申请人：NATHAN ILANA

  公开号：WO2016162870A1

  公开（公告）日：2016-10-13

  Inhibitor compounds and agents of Cathepsin C, CELA1, CELA3A and/or structurally related molecules thereto, compositions comprising same and uses thereof in the inhibition and/or prevention of cell and/or tissue necrosis is described. Various applications for the described compounds, and combination therapies are described as well.

  描述了抑制剂化合物和Cathepsin C、CELA1、CELA3A和/或与之结构相关的分子的作用剂，包括含有它们的组合物及其在抑制和/或预防细胞和/或组织坏死中的用途。还描述了所述化合物的各种应用和联合疗法。
• Compounds and Uses Thereof in Modulating Amyloid Beta
  申请人：Cheng Soan

  公开号：US20070260058A1

  公开（公告）日：2007-11-08

  Novel compounds, compositions, and kits are provided. Methods of modulating Aβ levels, and methods of treating a disease associated with aberrant Aβ levels are also provided.

  本发明提供了新的化合物、组合物和试剂盒。还提供了调节Aβ水平的方法以及治疗与异常Aβ水平相关的疾病的方法。
• COMPOUNDS AND USES THEREOF IN MODULATING AMYLOID BETA
  申请人：Cheng Soan

  公开号：US20100324032A1

  公开（公告）日：2010-12-23

  Novel compounds, compositions, and kits are provided. Methods of modulating Aβ levels, and methods of treating a disease associated with aberrant Aβ levels are also provided.

  本发明提供了新型化合物、组合物和试剂盒。还提供了调节Aβ水平的方法和治疗与异常Aβ水平相关的疾病的方法。
• COMPOSITIONS FOR TREATING AND/OR PREVENTING CELL OR TISSUE NECROSIS SPECIFICALLY TARGETING CATHEPSIN C AND/OR CELA1 AND/OR CELA3A AND/OR STRUCTURALLY RELATED ENZYMES THERETO
  申请人：ELA Pharma Ltd

  公开号：EP4005569A2

  公开（公告）日：2022-06-01

  Inhibitor compounds and agents of Cathepsin C, CELA1, CELA3A and/or structurally related molecules thereto, compositions comprising same and uses thereof in the inhibition and/or prevention of cell and/or tissue necrosis is described. Various applications for the described compounds, and combination therapies are described as well.

  本文描述了 Cathepsin C、CELA1、CELA3A 和/或其结构相关分子的抑制剂化合物和制剂、包含这些化合物的组合物及其在抑制和/或预防细胞和/或组织坏死方面的用途。此外还介绍了所述化合物的各种应用以及联合疗法。
• Substituted thiazoles for preventing and/or treating cell or tissue necrosis
  申请人：ELA PHARMA LTD

  公开号：US10968185B2

  公开（公告）日：2021-04-06

  Inhibitor compounds and agents of Cathepsin C, CELA1, CELA3A and/or structurally related molecules thereto, compositions comprising same and uses thereof in the inhibition and/or prevention of cell and/or tissue necrosis are described. The compounds include thiazoles of Formula II, where G1 is an optionally substituted pyrrolidine, an optionally substituted pyridine, an optionally substituted aryl, an optionally substituted piperidine, an optionally substituted piperazine, an optionally substituted imidazolidine, or an optionally substituted pyrazolidine. G3 is or G3 is an optionally substituted alkyl, an optionally substituted aryl or an optionally cyloalkyl. G2 is an optionally substituted alkyl, an optionally substituted aryl, an optionally substituted cyloalkyl or an optionally substituted heterocycle. Various applications for the described compounds, and combination therapies are described as well.

  本发明描述了 Cathepsin C、CELA1、CELA3A 和/或其结构相关分子的抑制剂化合物和制剂、包含这些化合物和制剂的组合物及其在抑制和/或预防细胞和/或组织坏死中的用途。这些化合物包括式 II 的噻唑类化合物、 其中 G1 是任选取代的吡咯烷、任选取代的吡啶、任选取代的芳基、任选取代的哌啶、任选取代的哌嗪、任选取代的咪唑烷或任选取代的吡唑烷。G3 是 或 G3 是任选取代的烷基、任选取代的芳基或任选取代的环烷基。G2 是任选取代的烷基、任选取代的芳基、任选取代的环烷基或任选取代的杂环。还介绍了所述化合物的各种应用以及组合疗法。