N-[7-(2-chlorophenyl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]benzamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-[7-(2-chlorophenyl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]benzamide
• 英文别名: N-[7-(2-chlorophenyl)-5-oxo-7,8-dihydro-6H-quinazolin-2-yl]benzamide
• 化学式: C₂₁H₁₆ClN₃O₂
• 分子量: 377.8
• InChiKey: XVXNNCXKMQIBSV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  72
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• INHIBITORS OF 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE FOR STIMULATING PIGMENTATION OF THE SKIN OR SKIN APPENDAGES
  申请人：MICHELET JEAN-FRANCOIS

  公开号：US20110014250A1

  公开（公告）日：2011-01-20

  Inhibitors of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), for example tetrazole, styrylpyrazole, phenylfuran, phenylthiophene, phenylpyrrazole, pyrazolecarboxamide, 2-thioacetamide and azo compounds, are useful for promoting or stimulating pigmentation of the skin and/or skin appendages and/or for preventing and/or for limiting depigmentation and/or whitening of the skin and/or skin appendages, notably for preventing and/or limiting canities.

  15-羟基前列腺素脱氢酶（15-PGDH）的抑制剂，例如四唑、苯乙烯吡唑、苯并呋喃、苯并硫吩、苯并吡唑、吡唑羧酰胺、2-硫代乙酰胺和偶氮化合物，可用于促进或刺激皮肤和/或皮肤附属物的色素沉着，或预防和/或限制皮肤和/或皮肤附属物的脱色和/或变白，特别是预防和/或限制白发。
• Cosmetic composition, method of cosmetic treatment and preparation of a composition for promoting the growth and/or preventing or delaying the loss of hair
  申请人：SOCIETE L'OREAL S.A.

  公开号：US20040052760A1

  公开（公告）日：2004-03-18

  The invention relates to a cosmetic composition containing at least one 15-hydroxyprostaglandin dehydrogenase inhibitor and cosmetically acceptable excipients. It also relates to a method of cosmetic treatment for promoting the growth and/or preventing or delaying the loss of hair, and the use of a 15-hydroxyprostaglandin dehydrogenase inhibitor for the preparation of a composition intended for controlling hair loss and/or for promoting hair regrowth.

  本发明涉及一种化妆品组合物，其含有至少一种15-羟基前列腺素脱氢酶抑制剂和化妆品可接受的辅料。本发明还涉及一种促进头发生长和/或预防或延迟脱发的化妆品治疗方法，以及使用15-羟基前列腺素脱氢酶抑制剂制备用于控制脱发和/或促进头发再生的组合物的用途。
• Composition cosmétique pour favoriser la pousse et/ou empecher ou retarder la chute des cheveux
  申请人：L'OREAL

  公开号：EP1358868A2

  公开（公告）日：2003-11-05

  L'invention concerne une composition cosmétique contenant au moins un inhibiteur de la 15-hydroxy prostaglandine déshydrogénase et des excipients cosmétologiquement acceptables. Elle concerne également un procédé de traitement cosmétique pour favoriser la pousse et/ou empêcher ou retarder la chute des cheveux, ainsi que l'utilisation d'un inhibiteur de 15-hydroxy prostaglandine déshydrogénase pour la préparation d'une composition destinée à lutter contre la chute des cheveux et/ou à favoriser la repousse des cheveux.

  本发明涉及一种含有至少一种 15-羟基前列腺素脱氢酶抑制剂和化妆品可接受赋形剂的化妆品组合物。 本发明还涉及一种促进头发生长和/或防止或延缓脱发的化妆品治疗方法，以及使用 15-羟基前列腺素脱氢酶抑制剂制备一种旨在防治脱发和/或促进头发再生的组合物。
• METHODS FOR STIMULATING OR INDUCING THE GROWTH AND/OR REDUCING THE LOSS OF KERATINOUS FIBERS
  申请人：MICHELET Jean-Francois

  公开号：US20080249117A1

  公开（公告）日：2008-10-09

  The invention relates to a cosmetic composition containing at least one 15-hydroxy-prostaglandin dehydrogenase inhibitor and cosmetically acceptable excipients. It also relates to a method of cosmetic treatment for promoting the growth and/or preventing or delaying the loss of hair, and the use of a 15-hydroxyprostaglandin dehydrogenase inhibitor for the preparation of a composition intended for controlling hair loss and/or for promoting hair regrowth.
• COMPOSITION COMPRISING AT LEAST ONE 15-PGDH INHIBITOR
  申请人：MICHELET Jean-Francois

  公开号：US20080206320A1

  公开（公告）日：2008-08-28

  The invention relates to a cosmetic composition containing at least one 15-hydroxy-prostaglandin dehydrogenase inhibitor and cosmetically acceptable excipients. It also relates to a method of cosmetic treatment for promoting the growth and/or preventing or delaying the loss of hair, and the use of a 15-hydroxyprostaglandin dehydrogenase inhibitor for the preparation of a composition intended for controlling hair loss and/or for promoting hair regrowth.