5-[(4-Hydroxyphenyl)methylidene]-3-(2-methylpropyl)-2-sulfanylidene-1,3-thiazolidin-4-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 5-[(4-Hydroxyphenyl)methylidene]-3-(2-methylpropyl)-2-sulfanylidene-1,3-thiazolidin-4-one
• 化学式: C₁₄H₁₅NO₂S₂
• 分子量: 293.4
• InChiKey: GPURHDUTZUYAFI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  97.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• INHIBITION OF ZSCAN4 FOR INHIBITION OF TUMOR GROWTH
  申请人：University of Maryland, Baltimore

  公开号：US20210079402A1

  公开（公告）日：2021-03-18

  Embodiments of the disclosure concern methods and compositions for treatment or prevention of cancer, such as through inhibition of the expression and/or activity of a telomere element that promotes telomere extension, such as ZSCAN4. In particular embodiments, inhibition of expression of ZSCAN4 with RNA interference strategies provides inhibition of proliferation of cancer cells that express ZSCAN4. Methods of sensitizing resistant cancers are also provided.
• [EN] INHIBITION OF ZSCAN4 FOR INHIBITION OF TUMOR GROWTH<br/>[FR] INHIBITION DE ZSCAN4 POUR L'INHIBITION DE LA CROISSANCE TUMORALE
  申请人：UNIV MARYLAND

  公开号：WO2019164965A1

  公开（公告）日：2019-08-29

  Embodiments of the disclosure concern methods and compositions for treatment or prevention of cancer, such as through inhibition of the expression and/or activity of a telomere element that promotes telomere extension, such as ZSCAN4. In particular embodiments, inhibition of expression of ZSCAN4 with RNA interference strategies provides inhibition of proliferation of cancer cells that express ZSCAN4. Methods of sensitizing resistant cancers are also provided.