4-amino-7-methyl-1H-pyrrolo[2,3-h]quinazolin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-amino-7-methyl-1H-pyrrolo[2,3-h]quinazolin-2-one
• 化学式: C₁₁H₁₀N₄O
• 分子量: 214.22
• InChiKey: ABPYBLNPIVYYGV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  72.4
• 氢给体数：
  2
• 氢受体数：
  1

文献信息

• OLIGONUCLEOTIDES FOR TREATING EXPANDED REPEAT DISEASES
  申请人：Sarepta Therapeutics, Inc.

  公开号：US20140303238A1

  公开（公告）日：2014-10-09

  The invention provides for a method for selectively reducing the expression of a mutant mRNA and/or protein having an expanded nucleotide repeat relative to a wild-type mRNA, comprising contacting a cell with an antisense oligonucleotide of sufficient length and complementarity to the expanded nucleotide repeat. More particularly it relates to selectively reducing the expression of mutant Huntington protein associated with Huntington's disease. The antisense oligonucleotide comprising either a nucleotide or a repeated three nucleotide sequence as defined in the claims.

  该发明提供了一种选择性减少具有扩展核苷酸重复相对于野生型mRNA的突变型mRNA和/或蛋白质表达的方法，包括将长度和互补性足够的反义寡核苷酸与细胞接触。更具体地，它涉及选择性减少与亨廷顿病相关的突变亨廷顿蛋白的表达。反义寡核苷酸包括在权利要求中定义的核苷酸或重复的三核苷酸序列。
• CHIRAL CONTROL
  申请人：WAVE LIFE SCIENCES PTE. LTD.

  公开号：US20150211006A1

  公开（公告）日：2015-07-30

  The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same. The invention specifically encompasses the identification of the source of certain problems with prior methodologies for preparing chiral oligonucleotides, including problems that prohibit preparation of fully chirally controlled compositions, particularly compositions comprising a plurality of oligonucleotide types. In some embodiments, the present invention provides chirally controlled oligonucleotide compositions. In some embodiments, the present invention provides methods of making chirally controlled oligonucleotides and chirally controlled oligonucleotide compositions.

  本发明涉及手性控制的寡核苷酸、手性控制的寡核苷酸组合物以及其制备和使用方法。本发明特别涵盖了鉴定以前制备手性寡核苷酸方法中某些问题的来源，包括禁止制备完全手性控制的组合物，特别是包含多种寡核苷酸类型的组合物。在某些实施例中，本发明提供了手性控制的寡核苷酸组合物。在某些实施例中，本发明提供了制备手性控制的寡核苷酸和手性控制的寡核苷酸组合物的方法。
• BIOPROBES AND METHODS OF USE THEREOF
  申请人：The Governing Council of the University of Toronto

  公开号：EP3369828B1

  公开（公告）日：2020-07-15
• METHOD FOR THE SYNTHESIS OF PHOSPHORUS ATOM MODIFIED NUCLEIC ACIDS
  申请人：Wada Takeshi

  公开号：US20110294124A1

  公开（公告）日：2011-12-01

  Described herein are methods of syntheses of phosphorous atom-modified nucleic acids comprising chiral X-phosphonate moieties. The methods described herein provide backbone-modified nucleic acids in high diasteteomeric purity via an asymmetric reaction of an achiral molecule comprising a chemically stable H-phophonate moiety with a nucleoside/nucleotide.
• NOVEL NUCLEIC ACID PRODRUGS AND METHODS OF USE THEREOF
  申请人：WAVE LIFE SCIENCES LTD.

  公开号：US20160347784A1

  公开（公告）日：2016-12-01

  Described herein are nucleic acid prodrugs and nucleic acid prodrugs comprising chiral phosphorous moieties. Also described herein are methods of making and using nucleic acid prodrugs and nucleic acid prodrugs comprising chiral phosphorous moieties.