6-methoxyspiro[2,4-dihydro-1H-isoquinoline-3,1'-cyclohexane] | 178976-86-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 6-methoxyspiro[2,4-dihydro-1H-isoquinoline-3,1'-cyclohexane]
• CAS: 178976-86-8
• 化学式: C₁₅H₂₁NO
• 分子量: 231.338
• InChiKey: MLZYYXJLVOWSGT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-methoxyspiro[2,4-dihydro-1H-isoquinoline-3,1'-cyclohexane] 在 sodium tungstate 、 双氧水 作用下， 以 乙醇 为溶剂， 生成 6-methoxy-2-oxidospiro[4H-isoquinolin-2-ium-3,1'-cyclohexane]
  参考文献：
  名称：

  Synthesis and radical scavenging activity of 3,3-dialkyl-3,4-dihydro-isoquinoline 2-oxides

  摘要：

  The syntheses and antioxidant activities of several cyclic nitrones related to phenyl t-butyl nitrone (PBN) are described. These nitrones may act as radical scavengers and have potential uses in the treatment of stroke and septic shock. (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00181-3
• 作为产物：
  描述：

  N-[1-(3-Methoxy-benzyl)-cyclohexyl]-formamide 在 sodium tetrahydroborate 、 硫酸 、 三氯化铁 作用下， 以 甲醇 为溶剂， 生成 6-methoxyspiro[2,4-dihydro-1H-isoquinoline-3,1'-cyclohexane]
  参考文献：
  名称：

  Synthesis and radical scavenging activity of 3,3-dialkyl-3,4-dihydro-isoquinoline 2-oxides

  摘要：

  The syntheses and antioxidant activities of several cyclic nitrones related to phenyl t-butyl nitrone (PBN) are described. These nitrones may act as radical scavengers and have potential uses in the treatment of stroke and septic shock. (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00181-3

文献信息

• Synthesis and radical scavenging activity of 3,3-dialkyl-3,4-dihydro-isoquinoline 2-oxides
  作者：Ronald C. Bernotas、Craig E. Thomas、Albert A. Carr、Thaddeus R. Nieduzak、Ginette Adams、David F. Ohlweiler、David A. Hay

  DOI：10.1016/0960-894x(96)00181-3

  日期：1996.5

  The syntheses and antioxidant activities of several cyclic nitrones related to phenyl t-butyl nitrone (PBN) are described. These nitrones may act as radical scavengers and have potential uses in the treatment of stroke and septic shock. (C) 1996 Elsevier Science Ltd