Chloro(cyclopentyl)methanol

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氯化物
• 英文名称: Chloro(cyclopentyl)methanol
• 英文别名: chloro(cyclopentyl)methanol
• 化学式: C₆H₁₁ClO
• 分子量: 134.6
• InChiKey: YKVWUCVKJNSODR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Inhibitors of lysine gingipain
  申请人：Cortexyme, Inc.

  公开号：US11332464B2

  公开（公告）日：2022-05-17

  The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its protease Lysine gingipain (Kgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I, as described herein, and pharmaceutically acceptable salts thereof.

  本发明一般涉及针对牙龈卟啉单胞菌（包括其蛋白酶赖氨酸龈肽酶（Kgp））的治疗药物，及其用于治疗与牙龈卟啉单胞菌感染相关的疾病，包括脑部疾病，如阿尔茨海默氏症。在某些实施方案中，本发明提供了本文所述的根据式 I 的化合物及其药学上可接受的盐。
• INHIBITORS OF LYSINE GINGIPAIN
  申请人：Cortexyme, Inc.

  公开号：US20210017167A1

  公开（公告）日：2021-01-21

  The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis , including its protease Lysine gingipain (Kgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I, as described herein, and pharmaceutically acceptable salts thereof.