4,6-Dimethylimidazo[1,2-a]quinoxaline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4,6-Dimethylimidazo[1,2-a]quinoxaline
• 英文别名: 4,6-dimethylimidazo[1,2-a]quinoxaline
• 化学式: C₁₂H₁₁N₃
• 分子量: 197.24
• InChiKey: JRJKSCHJUKKBJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• MESOSCALE NANOPARTICLES FOR SELECTIVE TARGETING TO THE KIDNEY AND METHODS OF THEIR THERAPEUTIC USE
  申请人：Memorial Sloan Kettering Cancer Center

  公开号：EP3297613A1

  公开（公告）日：2018-03-28
• [EN] MESOSCALE NANOPARTICLES FOR SELECTIVE TARGETING TO THE KIDNEY AND METHODS OF THEIR THERAPEUTIC USE<br/>[FR] NANOPARTICULES À ÉCHELLE MOYENNE PERMETTANT LE CIBLAGE SÉLECTIF DE REIN, ET PROCÉDÉS POUR LEUR UTILISATION THÉRAPEUTIQUE
  申请人：MEMORIAL SLOAN KETTERING CANCER CENTER

  公开号：WO2016153920A1

  公开（公告）日：2016-09-29

  A drug carrier nanoparticle has been synthesized that can specifically target the proximal tubules of the kidneys. The nanoparticles accumulate in the kidneys to a greater extent than other organs (e.g., up to 3 or more times greater in the kidney than any other organ). They can encapsulate many classes of drug molecules. The nanoparticles are biodegradable and release the drug as they degrade. The particles can sustainably release a drug within the kidneys for up to two months. The nanoparticles are useful for the treatment of diseases that affect the proximal tubules, such as heart failure, liver cirrhosis, hypertension, and renal failure; the study of relative blood flow to the renal cortex and medulla; and delivery of agents to treat gout.