2-N-(3,5-dimethylphenyl)-4-N-(oxolan-2-ylmethyl)quinazoline-2,4-diamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-N-(3,5-dimethylphenyl)-4-N-(oxolan-2-ylmethyl)quinazoline-2,4-diamine
• 化学式: C₂₁H₂₄N₄O
• 分子量: 348.4
• InChiKey: CUGMIWICGZQINV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  59.1
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• SMALL MOLECULE INHIBITORS OF BACTERIAL MOTILITY AND A HIGH THROUGHPUT SCREENING ASSAY FOR THEIR IDENTIFICATION
  申请人：Pathak Ashish K.

  公开号：US20120108615A1

  公开（公告）日：2012-05-03

  Certain compounds are provided that can selectively inhibit motile bacteria such as V. cholerae motility. These compounds can indirectly diminish production of cholera toxin and other major virulence required by the cholera bacterium to cause disease.
• US8940740B2
  申请人：——

  公开号：US8940740B2

  公开（公告）日：2015-01-27
• [EN] SMALL MOLECULE INHIBITORS OF BACTERIAL MOTILITY AND A HIGH THROUGHPUT SCREENING ASSAY FOR THEIR IDENTIFICATION<br/>[FR] PETITES MOLÉCULES INHIBITRICES DE LA MOTILITÉ BACTÉRIENNE ET ESSAI DE CRIBLAGE À HAUT DÉBIT POUR LES IDENTIFIER
  申请人：SOUTHERN RES INST

  公开号：WO2012058601A1

  公开（公告）日：2012-05-03

  Certain compounds are provided that can selectively inhibit motile bacteria such as V. cholerae motility. These compounds can indirectly diminish production of cholera toxin and other major virulence required by the cholera bacterium to cause disease.