N-{4-[1-acetyl-5-(quinoxalin-6-yl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl}methanesulfonamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-{4-[1-acetyl-5-(quinoxalin-6-yl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl}methanesulfonamide
• 英文别名: N-[4-(2-acetyl-3-quinoxalin-6-yl-3,4-dihydropyrazol-5-yl)phenyl]methanesulfonamide
• 化学式: C₂₀H₁₉N₅O₃S
• 分子量: 409.5
• InChiKey: NLKRGNCKUGWQFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  113
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Pyrazolines for the Modulation of PKM2
  申请人：Becker Oren M.

  公开号：US20120302609A1

  公开（公告）日：2012-11-29

  The invention relates to pyrazoline substituted compounds and methods for activating PKM2. The compounds and methods are useful in treating or preventing a disease or disorder selected from cancer, cell proliferative disorder, inflammatory disorder, metabolic disorder, and immune system disorder.

  该发明涉及取代吡唑啉化合物和激活PKM2的方法。这些化合物和方法在治疗或预防癌症、细胞增殖紊乱、炎症性疾病、代谢紊乱和免疫系统紊乱等疾病或疾病中具有用途。
• [EN] 3, 5 -DIPHENYL- SUBSTITUTED PYRAZOLINES FOR THE TREATMENT OF CANCER, PROLIFERATIVE, INFLAMMATORY OR AUTOIMMUNE DISEASES<br/>[FR] PYRAZOLINES 3,5-DIPHÉNYL SUBSTITUÉES POUR LE TRAITEMENT DU CANCER, DE MALADIES PROLIFÉRATIVES, INFLAMMATOIRES OU AUTO-IMMUNES
  申请人：DYNAMIX PHARMACEUTICALS LTD

  公开号：WO2012160447A1

  公开（公告）日：2012-11-29

  The invention relates to pyrazoline substituted compounds and methods for activating PKM2. The compounds and methods are useful in treating or preventing a disease or disorder selected from cancer, cell proliferative disorder, inflammatory disorder, metabolic disorder, and immune system disorder.