2-Ethyl-2-(methylamino)butanal

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-Ethyl-2-(methylamino)butanal
• 英文别名: 2-ethyl-2-(methylamino)butanal
• 化学式: C₇H₁₅NO
• 分子量: 129.2
• InChiKey: YAMIRAGSWQOFMP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• PEPTIDOMIMETIC MACROCYCLES WITH PTH ACTIVITY
  申请人：AILERON THERAPEUTICS, INC.

  公开号：US20170037086A1

  公开（公告）日：2017-02-09

  The present invention provides peptidomimetic macrocycles capable of modulating parathyroid hormone levels and methods of using such macrocycles for the treatment of disease.
• [EN] PEPTIDOMIMETIC MACROCYCLES AS MODULATORS OF MCL-1<br/>[FR] MACROCYCLES PEPTIDOMIMÉTIQUES EN TANT QUE MODULATEURS DE MCL-1
  申请人：AILERON THERAPEUTICS INC

  公开号：WO2017044633A1

  公开（公告）日：2017-03-16

  The disclosed peptidomimetic macrocycles such as Formula (Ic) that can modulate the activity of MCL-1. Myeloid cell leukemia 1 (MCL-1) is a protein that inhibits cell death. Peptidomimetic macrocycles, pharmaceutical compositions, and methods disclosed herein can be used for the treatment of disease in which MCL-1 is over-expressed, such as cancer. In particular, MCL- 1 -modulating peptidomimetic macrocycles disclosed herein can be applied in the setting of resistance to BCL-2 family inhibitors, which is often engendered by MCL-1 over-expression or hyperactivation.