N-{4-[(2-amino-4-oxo-3,4,7,8-tetrahydro-pteridin-6-ylmethyl)-amino]-benzoyl}-glutamic acid | 15574-38-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 英文名称: N-{4-[(2-amino-4-oxo-3,4,7,8-tetrahydro-pteridin-6-ylmethyl)-amino]-benzoyl}-glutamic acid
• 英文别名: Dihy-drofolic acid；(2R)-2-[[4-[(2-amino-4-oxo-7,8-dihydro-3H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
• CAS: 15574-38-6
• 化学式: C₁₉H₂₁N₇O₆
• 分子量: 443.419
• InChiKey: OZRNSSUDZOLUSN-GFCCVEGCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  208
• 氢给体数：
  7
• 氢受体数：
  10

文献信息

• PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE AMINE DERIVATIVE
  申请人：Nagasawa Toru

  公开号：US20110287494A1

  公开（公告）日：2011-11-24

  Novel enzymes that stereoselectively reduce imine derivatives were isolated and purified, and polynucleotides encoding the enzymes were cloned. Optically active amine derivatives were produced by acting on imine derivatives with a culture of microorganisms having the ability to stereoselectively reduce the compounds, microbial cells or processed products thereof, and/or imine reductases thereof, followed by collecting the generated optically active amine derivatives. The present invention enables, for example, production of an optically active compound represented by formula (IV): (wherein R group represents an alkyl group having one to three carbon atoms; and n represents an integer of 1 to 4).

  本发明分离和纯化了立体选择性还原亚胺衍生物的新型酶，并克隆了编码该酶的多核苷酸。通过使用具有立体选择性还原化合物能力的微生物培养物，微生物细胞或其处理产品和/或亚胺还原酶，对亚胺衍生物进行作用，生成光学活性胺衍生物，然后收集所产生的光学活性胺衍生物。例如，本发明使得能够生产由公式（IV）表示的光学活性化合物：（其中R基表示具有1至3个碳原子的烷基；n表示1至4的整数）。