2,5-Bis(4-guanidino-3-methoxyphenyl)furan

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 英文名称: 2,5-Bis(4-guanidino-3-methoxyphenyl)furan
• 英文别名: 1-[4-[5-(4-Guanidino-3-methoxy-phenyl)-2-furyl]-2-methoxy-phenyl]guanidine；2-[4-[5-[4-(diaminomethylideneamino)-3-methoxyphenyl]furan-2-yl]-2-methoxyphenyl]guanidine
• 化学式: C₂₀H₂₂N₆O₃
• 分子量: 394.433
• InChiKey: FJLOEWWZWCJKNF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  160
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  C₁₈H₁₈N₂O₃ 在 盐酸 、 TEA 、 mercury dichloride 作用下， 以 乙醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 2,5-Bis(4-guanidino-3-methoxyphenyl)furan
  参考文献：
  名称：

  The activity of diguanidino and ‘reversed’ diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani

  摘要：

  The in vitro activity of 20 dicationic molecules containing either diguanidino or reversed amidine cationic groups were evaluated versus Trypanosoma cruzi and Leishmania donovani. The most active compounds were in the reversed amidine series and six exhibited IC50 values of less than 1 mumol versus T. cruzi and five gave similar values versus L. donovani. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00319-6

文献信息

• Reversed amidines and methods of using for treating, preventing, or inhibiting leishmaniasis
  申请人：——

  公开号：US20020156098A1

  公开（公告）日：2002-10-24

  Methods for treating, preventing or inhibiting leishmaniasis in a subject comprising administering to the subject a therapeutically effective amount of at least one compound having the structural formula 1 wherein Y is a heteroatom; R 1 and R 2 are independently H or an alkyl, cycloalkyl, heterocycloalkyl, aryl, amino or heteroaryl group; and X 1 , X 2 , and X 3 are independently H or an alkyl, alkoxy, halo, amino, alkylamino, dialkylamino, acylamino, alkylthio, sulfonyl, cyano, carboxy, alkoxycarbonyl, or carbamoyl group are disclosed.

  本发明涉及用于治疗、预防或抑制利什曼病的方法，包括向受试者施用至少一种具有结构式1的化合物的治疗有效量，其中Y是杂原子；R1和R2分别是H或烷基、环烷基、杂环烷基、芳基、氨基或杂芳基基团；X1、X2和X3分别是H或烷基、烷氧基、卤素、氨基、烷基氨基、二烷基氨基、酰胺基、烷硫基、磺酰基、氰基、羧基、烷氧羰基或氨基甲酰基基团。
• US6706754B2
  申请人：——

  公开号：US6706754B2

  公开（公告）日：2004-03-16
• [EN] REVERSED AMIDINES AND METHODS OF USING FOR TREATING, PREVENTING, OR INHIBITING LEISHMANIASIS<br/>[FR] AMIDINES INVERSEES ET METHODES D'UTILISATION POUR TRAITER, PREVENIR, ET INHIBER LA LEISHMANIOSE
  申请人：US ARMY MED RES MAT COMMAND

  公开号：WO2002036588A2

  公开（公告）日：2002-05-10

  Methods for treating, preventing or inhibiting leishmaniasis in a subject comprising administering to the subject a therapeutically effective amount of at least one compound having the structural formula (I) wherein Y is a heteroatom; R?1 and R2¿ are independently H or an alkyl, cycloalkyl, heterocycloalkyl, aryl, amino or heteroaryl group; and X1, X2, and X¿3? are independently H or an alkyl, alkoxy, halo, amino, alkylamino, dialkylamino acylamino, alkylthio, sulfonyl, cyano, carboxy alkoxycarbonyl, or carbamoyl group are disclosed.