8-Chloro-4-hydroxy-2-methyl-4H-benzo[1,4]oxazin-3-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 8-Chloro-4-hydroxy-2-methyl-4H-benzo[1,4]oxazin-3-one
• 英文别名: 8-Chloro-4-hydroxy-2-methyl-1,4-benzoxazin-3-one
• 化学式: C₉H₈ClNO₃
• 分子量: 213.62
• InChiKey: XJNAMXJJFMHKNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氯-6-硝基苯酚 在 potassium methanolate 、 氯化铵 、 锌 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 2.5h， 生成 8-Chloro-4-hydroxy-2-methyl-4H-benzo[1,4]oxazin-3-one
  参考文献：
  名称：

  Synthesis and antimicrobial activity of some new 4-hydroxy-2H-1,4-benzoxazin-3(4H)-ones

  摘要：

  Some 4-hydroxy-2H-1,4-benzoxazin-3(4H)-ones were synthesized and evaluated for their antimicrobial activities against Staphylococcus aureus, Escherichia coli and Candida albicans. Compounds 9, and 10 exhibited the best activity against Candida albicans. (C) 2000 Published by Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(00)00098-7

文献信息

• Synthesis and antimicrobial activity of some new 4-hydroxy-2H-1,4-benzoxazin-3(4H)-ones
  作者：Seçkin Özden、Aydin Murat Öztürk、Hakan Göker、Nurten Altanlar

  DOI：10.1016/s0014-827x(00)00098-7

  日期：2000.12

  Some 4-hydroxy-2H-1,4-benzoxazin-3(4H)-ones were synthesized and evaluated for their antimicrobial activities against Staphylococcus aureus, Escherichia coli and Candida albicans. Compounds 9, and 10 exhibited the best activity against Candida albicans. (C) 2000 Published by Elsevier Science S.A. All rights reserved.