N-ethanimidoyl-2-methylpropanamide

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-ethanimidoyl-2-methylpropanamide
• 化学式: C₆H₁₂N₂O
• 分子量: 128.17
• InChiKey: TXXQUWLVCVNKFB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• TAU-TARGETING OLIGONUCLEOTIDE GAPMERS
  申请人：Eisai R&D Management Co., Ltd.

  公开号：US20220195437A1

  公开（公告）日：2022-06-23

  Antisense oligonucleotides are provided. These antisense oligonucleotides are useful in the preparation of gapmers for inhibition of Tau mRNA transcription. Inhibition of Tau mRNA transcription may result in decrease of amounts of Tau protein in a subject, allowing treatment of diseases and disorders related to expression of Tau, including Alzheimer's disease and primary tauopathies.

  提供了反义寡核苷酸。这些反义寡核苷酸在制备gapmers以抑制Tau mRNA转录方面非常有用。抑制Tau mRNA转录可能导致受试者Tau蛋白质量的降低，从而治疗与Tau表达有关的疾病和疾病，包括阿尔茨海默病和原发性Tau病。
• SULFONAMIDE COMPOUND
  申请人：Mitsubishi Tanabe Pharma Corporation

  公开号：EP2896613A1

  公开（公告）日：2015-07-22

  The present invention provides novel sulfonamide compounds having TRPM8 antagonistic activity which are useful as medicaments. Specifically, the present invention provides a sulfonamide compound of the formula (I): wherein Ring A is the following formula (i), (ii), or (ix): R4 is optionally substituted alkyl, X1 and X2 are each independently tetrazolyl, tetrazolinonyl, optionally substituted triazolyl, triazolinonyl, oxadiazolonyl, optionally substituted alkanoylaminomethyl, or optionally substituted alkylsulfonylaminomethyl, or R4 and X2 combine with each other at their terminals together with the adjacent benzene to form indazolinonyl or benzoisoxazolonyl, and the other symbols are the same as described in the specification, or a pharmaceutically acceptable salt thereof.

  本发明提供了具有 TRPM8 拮抗活性的新型磺酰胺化合物，可用作药物。具体而言，本发明提供了一种式（I）的磺酰胺化合物： 其中环 A 为下式(i)、(ii)或(ix)： R4 是任选取代的烷基、 X1和X2各自独立地为四唑基、四唑啉基、任选取代的三唑基、三唑啉基、噁二唑啉基、任选取代的烷酰氨基甲基或任选取代的烷磺酰氨基甲基，或 R4 和 X2 在其末端与相邻的苯相互结合形成吲唑啉基或苯并异噁唑啉基，以及 其他符号与说明书中描述的相同、 或其药学上可接受的盐。