2-[Bis(2-hydroxyethyl)amino]ethanol;1-dodecoxydodecane;sulfuric acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫酸及其衍生物
• 英文名称: 2-[Bis(2-hydroxyethyl)amino]ethanol;1-dodecoxydodecane;sulfuric acid
• 化学式: C30H67NO8S
• 分子量: 601.9
• InChiKey: GWEBEJYKXBMRJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.46
• 重原子数：
  40
• 可旋转键数：
  28
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  156
• 氢给体数：
  5
• 氢受体数：
  9

文献信息

• Composition for the cleaning of skin, scalp and hair
  申请人：Crinos Industria Farmacobiologica S.p.A.

  公开号：EP0530865A1

  公开（公告）日：1993-03-10

  The invention discloses compositions in the form of aqueous solutions or O/W emulsions for the cleaning of skin, scalp and hair, characterized in that they contain from 0,5 to 5% w/v of at least one water soluble organic base chosen in the group consisting of low molecular weight saturated aliphatic alkylamines, their hydroxy derivatives, low molecular weight primary alkylenediamines, basic aminoacids. Said water soluble organic base are buffered at pH 7-9. The cleaning efficacy of said preparations may be increased by adding lipases in a quantity ranging from 0,1 to 1% w/v. According to a further embodiment of the invention, in said compositions can be comprised detergents in a quantity not exceeding 4% w/v. The compositions are endowed of the property of cleaning the skin in a delicate manner, with a good local tolerability.

  本发明公开了用于清洁皮肤、头皮和头发的水溶液或油/水乳液形式的组合物，其特征在于它们含有 0.5% 至 5% w/v 的至少一种水溶性有机碱，该有机碱可从低分子量饱和脂肪族烷基胺、其羟基衍生物、低分子量伯烷基二胺、碱性氨基酸组成的组中选择。所述水溶性有机碱的缓冲pH值为 7-9。 可以通过添加脂肪酶来提高上述制剂的清洁效果，添加量为 0.1%至 1%（重量/体积）。 根据本发明的另一个实施方案，在所述组合物中可以加入不超过 4% w/v 的洗涤剂。 这些组合物具有细腻清洁皮肤的特性，并具有良好的局部耐受性。
• Amino acid derivatives and compositions containing the same for inhibiting active-oxygen
  申请人：Ajinomoto Co., Inc.

  公开号：EP0869115A2

  公开（公告）日：1998-10-07

  A novel active oxygen-resisting agent is provided which has an excellent active oxygen resistance and which exhibits a good solubility in an oil solvent. The active oxygen-resisting agent contains as an active ingredient an amino acid derivative represented by the following formula (I) or its salt wherein Ar represents a 2-hydroxyphenyl group or a pyridyl group (one or more of hydrogen atoms bound to the aromatic rings of these groups may be substituted independently with a halogen atom, an alkyl group having from 1 to 6 carbon atoms, a hydroxyl group, a hydroxyalkyl group having from 1 to 6 carbon atoms, a nitro group, an alkoxyl group having from 1 to 6 carbon atoms or a carboxyl group), R1 represents a side chain of an animo acid, X represents -O- or -NH-, R2 represents an alkyl group having from 8 to 22 carbon atoms, and n represents 0 or 1.

  本发明提供了一种新型活性抗氧剂，它具有极佳的活性抗氧性，并且在油溶剂中具有良好的溶解性。 该活性抗氧剂的活性成分是由下式（I）或其盐代表的氨基酸衍生物 其中 Ar 代表 2-羟基苯基或吡啶基（与这些基团的芳香环结合的一个或多个氢原子可独立地被卤素原子、1-6 个碳原子的烷基、羟基、1-6 个碳原子的羟烷基、硝基、1-6 个碳原子的烷氧基或羧基取代）、 R1 代表亚胺酸的侧链、 X 代表-O-或-NH-、 R2 代表具有 8 至 22 个碳原子的烷基，以及 n 代表 0 或 1。
• NOVEL CYSTINE DERIVATIVES AND INHIBITORS FOR THE ACTIVATION OF INFLAMMATORY FACTORS
  申请人：Ajinomoto Co., Inc.

  公开号：EP1364943A1

  公开（公告）日：2003-11-26

  A novel cystine derivative of a specific structure, such as N,N'-bis(2-hydroxybenzyl)-L-cystine (which may be in any form of free form, salt, solvate and the like) has been found to have an excellent action to suppress the activation of inflammatory factors. By using the derivative as an effective ingredient, an excellent agent for suppressing the activation of inflammatory factors can be provided. Additionally, the cystine derivative is preferably used for a method for suppressing the activation of inflammatory factors (in particular a method for preventing, ameliorating and/or therapeutically treating diseases (disorders), or skin injuries or disorders involved in the activation of inflammatory factors, a method for preventing, delaying, ameliorating and/or therapeutically treating skin change via aging or aesthetically unfavorable skin change as induced or promoted by inflammatory factors, and the like) and for pharmaceutical agents (pharmaceutical products; external skin application agents, eye drops, nutrition agents, transfusion and the like), cosmetics, foods or drinks and the like which are specific use applications to the agent for suppressing the activation of inflammatory factors. The invention also provides the novel cystine derivative with the excellent action to suppress the activation of inflammatory factors, which can be used as the effective ingredient described above, and a method for producing the same, and additionally provides the method for suppressing the activation of inflammatory factors described above, a use of the cystine derivative (active ingredient) described above for the agent for suppressing the activation of inflammatory factors, and the like.

  研究发现，一种具有特定结构的新型胱氨酸衍生物，如 N,N'-双（2-羟基苄基）-L-胱氨酸（可以是游离态、盐、溶液等任何形式），在抑制炎症因子活化方面具有出色的作用。通过使用该衍生物作为有效成分，可以提供一种抑制炎症因子活化的极佳制剂。此外，胱氨酸衍生物优选用于抑制炎症因子活化的方法（特别是预防、改善和/或治疗涉及炎症因子活化的疾病（失调）或皮肤损伤或失调的方法，预防、延缓、改善和/或治疗由炎症因子诱发或促进的皮肤老化或美观上不利的皮肤变化的方法等）和药物制剂（医药产品；外用皮肤涂抹剂、眼药水、营养剂、输血等）、化妆品、食品或饮料等，这些都是抑制炎症因子活化的药剂的特定用途应用。 本发明还提供了具有良好抑制炎症因子活化作用、可用作上述有效成分的新型胱氨酸衍生物及其生产方法，此外还提供了上述抑制炎症因子活化的方法、上述胱氨酸衍生物（有效成分）在抑制炎症因子活化制剂中的用途等。
• Polishing composition
  申请人：FUJIMI INCORPORATED

  公开号：EP1520892A2

  公开（公告）日：2005-04-06

  A polishing composition of the present invention, to be used in polishing for forming wiring in a semiconductor device, includes: a specific surfactant; a silicon oxide; at least one selected from the group consisting of carboxylic acid and alpha-amino acid; a corrosion inhibitor; an oxidant; and water. This polishing composition is capable of suppressing the occurrence of the dishing.

  本发明的一种抛光组合物用于半导体器件中形成布线的抛光，包括：特定的表面活性剂；氧化硅；从羧酸和α-氨基酸组成的组中选出的至少一种；腐蚀抑制剂；氧化剂；以及水。这种抛光组合物能够抑制分层现象的发生。
• Ophthalmic composition
  申请人：Omnivision GmbH

  公开号：EP2452669A1

  公开（公告）日：2012-05-16

  The present invention relates to an aqueous ophthalmic composition comprising (i) a prostaglandin; and (ii) one or more anionic surfactants, characterized in that the concentration of anionic surfactant in the ophthalmic composition is from 0.001 to 1.0 g/L.

  本发明涉及一种水性眼科组合物，其中包括 (i) 前列腺素；和 (ii) 一种或多种阴离子表面活性剂、 其特征在于 眼科组合物中阴离子表面活性剂的浓度为 0.001 至 1.0 克/升。