Compositions containing a complex that contains a cation with alkyl chains and a macromolecule anion, and methods of making and using are disclosed. The compositions are typically charge neutral and a liquid at room temperature and standard pressure. The macromolecule anions may be nucleic acids, peptides, proteins, and/or carbohydrates. The compositions have enhanced penetration across the skin barrier (stratum corneum) and into the skin cells, delivering the macromolecules to the skin cells. The compositions are topically applied to the skin and are particularly useful for treatment of skin conditions.
本发明揭示了含有含有烷基链阳离子和大分子阴离子的复合物的组合物及其制备和使用方法。这些组合物通常是电中性的,且在常温和标准压力下呈液态。大分子阴离子可以是核酸、肽、蛋白质和/或
碳水化合物。这些组合物可以增强穿透皮肤屏障(角质层)并进入皮肤细胞,将大分子输送到皮肤细胞中。这些组合物可局部应用于皮肤,尤其适用于治疗皮肤状况。