5-hydroxymethyl-3-(4-hydroxy-phenyl)-oxazolidin-2-one | 64589-71-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 5-hydroxymethyl-3-(4-hydroxy-phenyl)-oxazolidin-2-one
• 英文别名: 3-[(4-Hydroxy)phenyl]-5-hydroxymethyl-2-oxazolidinone；5-(hydroxymethyl)-3-(4-hydroxyphenyl)-1,3-oxazolidin-2-one
• CAS: 64589-71-5
• 化学式: C₁₀H₁₁NO₄
• 分子量: 209.202
• InChiKey: WVULNOZIAYBGLE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  70
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-hydroxymethyl-3-(4-hydroxy-phenyl)-oxazolidin-2-one 、 1-[bromo(tritio)methyl]-3-chlorobenzene 生成 3-[4-[(3-chlorophenyl)-tritiomethoxy]phenyl]-5-(hydroxymethyl)-1,3-oxazolidin-2-one
  参考文献：
  名称：

  GATES, KENT S.;SILVERMAN, RICHARD B., J. AMER. CHEM. SOC., 112,(1990) N5, C. 9364-9372

  摘要：

  DOI：
• 作为产物：
  描述：

  3-(4-benzyloxy-phenyl)-5-hydroxymethyl-oxazolidin-2-one 生成 5-hydroxymethyl-3-(4-hydroxy-phenyl)-oxazolidin-2-one
  参考文献：
  名称：

  GATES, KENT S.;SILVERMAN, RICHARD B., J. AMER. CHEM. SOC., 112,(1990) N5, C. 9364-9372

  摘要：

  DOI：

文献信息

• 3-aryloxazolidinone derivatives, process for their preparation and their
  申请人：Delalande S.A.

  公开号：US05196543A1

  公开（公告）日：1993-03-23

  The derivatives of the formula: ##STR1## wherein: R.sub.1 is H or C.sub.1 -C.sub.4 alkyl; X is either an oxygen atom, in which case R.sub.2 =H or halogen, or a methylene group or a --CH.dbd.CH-- group, in which case R.sub.2 =H; n is 1 or 2 when X is an oxygen atom or a methylene group and 0 or 1 when X is a --CH.dbd.CH-- group; each of R.sub.3 and R.sub.4 is independently H, C.sub.1 -C.sub.4 alkyl, C.sub.4 -C.sub.7 cycloalkyl, phenyl or benzyl; R.sub.5 is H or C.sub.1 -C.sub.4 alkyl; R.sub.6 is C.sub.1 -C.sub.4 alkyl, CHF.sub.2, CF.sub.3, CF.sub.3 CF.sub.2, C.sub.4 -C.sub.7 cycloalkyl, phenyl or benzyl; R.sub.4 and R.sub.6 may further form together a --(CH.sub.2).sub.3 -- or --(CH.sub.2).sub.4 --chain; R.sub.5 and R.sub.6 may further form together a --(CH.sub.2).sub.4 --or --(CH.sub.2).sub.5 --chain; and R.sub.7 is H, C.sub.1 -C.sub.4 alkyl, C.sub.2 -C.sub.5 acyl or benzyl, useful as drugs, prepared by cyclizing N ethoxy carbonyl anilines with substituted 1, 3 dioxolane-2-ones.

  该公式的导数：##STR1## 其中：R.sub.1是H或C.sub.1-C.sub.4烷基；X是氧原子，此时R.sub.2=H或卤素，或是亚甲基基团或--CH.dbd.CH--基团，此时R.sub.2=H；当X是氧原子或亚甲基基团时，n为1或2，当X是--CH.dbd.CH--基团时，n为0或1；R.sub.3和R.sub.4中的每一个独立地是H、C.sub.1-C.sub.4烷基、C.sub.4-C.sub.7环烷基、苯基或苄基；R.sub.5是H或C.sub.1-C.sub.4烷基；R.sub.6是C.sub.1-C.sub.4烷基、CHF.sub.2、CF.sub.3、CF.sub.3 CF.sub.2、C.sub.4-C.sub.7环烷基、苯基或苄基；R.sub.4和R.sub.6还可以共同形成--(CH.sub.2).sub.3--或--(CH.sub.2).sub.4--链；R.sub.5和R.sub.6还可以共同形成--(CH.sub.2).sub.4--或--(CH.sub.2).sub.5--链；R.sub.7是H、C.sub.1-C.sub.4烷基、C.sub.2-C.sub.5酰基或苄基，可用作药物，通过将N乙氧羰基苯胺与取代的1,3-二氧杂环己烷-2-酮环化制备。
• 3-Aryloxazolidinone derivatives, process for their preparation and their
  申请人：Delalande S.A.

  公开号：US05036091A1

  公开（公告）日：1991-07-30

  The derivatives of the formula: ##STR1## wherein: R.sub.1 is H or C.sub.1 -C.sub.4 alkyl; X is either an oxygen atom, in which case R.sub.2 =H or halogen, or a methylene group or a --CH.dbd.CH-- group, in which case R.sub.2 =H; n is 1 or 2 when X is an oxygen atom or a methylene group and 0 or 1 when X is a --CH.dbd.CH-- group; each of R.sub.3 and R.sub.4 is independently H, C.sub.1 -C.sub.4 alkyl, C.sub.4 -C.sub.7 cycloalkyl, phenyl or benzyl; R.sub.5 is H or C.sub.1 -C.sub.4 alkyl; R.sub.6 is C.sub.1 -C.sub.4 alkyl, CHF.sub.2, CF.sub.3, CF.sub.3 CH.sub.2, C.sub.4 -C.sub.7 cycloalkyl, phenyl or benzyl; R.sub.4 and R.sub.6 may further form together a --(CH.sub.2).sub.3 -- or --(CH.sub.2).sub.4 -- chain; R.sub.5 and R.sub.6 may further form together a --(CH.sub.2).sub.4 -- or --(CH.sub.2).sub.5 -- chain; and R.sub.7 is H, C.sub.1 -C.sub.4 alkyl, C.sub.2 -C.sub.5 acyl or benzyl, useful as drugs.

  该公式的衍生物：##STR1## 其中：R.sub.1是H或C.sub.1-C.sub.4烷基; X是氧原子，此时R.sub.2=H或卤素，或是亚甲基基团或--CH.dbd.CH--基团，此时R.sub.2=H; 当X是氧原子或亚甲基基团时，n为1或2，当X是--CH.dbd.CH--基团时，n为0或1; R.sub.3和R.sub.4各自独立地为H，C.sub.1-C.sub.4烷基，C.sub.4-C.sub.7环烷基，苯基或苄基; R.sub.5是H或C.sub.1-C.sub.4烷基; R.sub.6是C.sub.1-C.sub.4烷基，CHF.sub.2，CF.sub.3，CF.sub.3 CH.sub.2，C.sub.4-C.sub.7环烷基，苯基或苄基; R.sub.4和R.sub.6还可以共同形成一个--(CH.sub.2).sub.3--或--(CH.sub.2).sub.4--链; R.sub.5和R.sub.6还可以共同形成一个--(CH.sub.2).sub.4--或--(CH.sub.2).sub.5--链; R.sub.7是H，C.sub.1-C.sub.4烷基，C.sub.2-C.sub.5酰基或苄基，是有用的药物。
• DOSTERT, P.;DOUZON, C.;BOURGERY, G.;GOURET, C.;MOCQUET, G.
  作者：DOSTERT, P.、DOUZON, C.、BOURGERY, G.、GOURET, C.、MOCQUET, G.

  DOI：——

  日期：——
• US4150029A
  申请人：——

  公开号：US4150029A

  公开（公告）日：1979-04-17
• US4155935A
  申请人：——

  公开号：US4155935A

  公开（公告）日：1979-05-22