6-Hydroxy-5-methyl-naphthoe-2-saeure | 948-58-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 6-Hydroxy-5-methyl-naphthoe-2-saeure
• 英文别名: 6-hydroxy-5-methyl-[2]naphthoic acid；6-Hydroxy-5-methyl-[2]naphthoesaeure；6-Hydroxy-5-methyl-naphthalene-2-carboxylic acid；6-hydroxy-5-methylnaphthalene-2-carboxylic acid
• CAS: 948-58-3
• 化学式: C₁₂H₁₀O₃
• 分子量: 202.21
• InChiKey: XKFNZRZICQABOD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-Hydroxy-5-methyl-naphthoe-2-saeure 在 溶剂黄146 、 铂 作用下， 生成 5-methyl-decahydro-[2]naphthoic acid
  参考文献：
  名称：

  73.合成与甾醇有关的物质的实验。XXX部分

  摘要：

  DOI：

  10.1039/jr9410000386
• 作为产物：
  描述：

  6-Methoxy-5-methyl-naphthoe-2-saeure 在 氢碘酸 、 溶剂黄146 作用下， 生成 6-Hydroxy-5-methyl-naphthoe-2-saeure
  参考文献：
  名称：

  73.合成与甾醇有关的物质的实验。XXX部分

  摘要：

  DOI：

  10.1039/jr9410000386

文献信息

• Liquid-crystalline polyester production method
  申请人：Ohtomo Shinji

  公开号：US20050080227A1

  公开（公告）日：2005-04-14

  A liquid-crystalline polyester production method with a shortened reaction time and improved productivity per unit time by using an organic basic compound containing one nitrogen atom in a molecule is achieved by a liquid-crystalline polyester production method comprising carrying out acylation reaction and/or ester-exchange in the presence of an organic basic compound containing one nitrogen atom in one molecule and satisfying the following inequality (1): 0< A+ 0.4× B (1) wherein, A and B satisfy A=(Ec h+ −Ec)/(Ep h+ −Ep)}−1 and B=(φf/φfp)−1; Ec denotes the heat of formation of the organic basic compound; Ec h+ denotes the heat of formation of a compound coordinated by proton; Ep denotes the heat of formation of pyridine; and Ep h+ denotes the heat of formation of pyridine coordinated by proton to the nitrogen atom; φf and φfp independently denote parameters relevant to the steric angles.

  通过使用分子中含有一个氮原子的有机碱性化合物，实现了一种缩短反应时间和提高单位时间生产率的液晶聚酯生产方法，其包括在有机碱性化合物的存在下进行酰化反应和/或酯交换，并满足以下不等式(1)：0
• Compounds and methods of use
  申请人：Potashman Michele

  公开号：US20060241115A1

  公开（公告）日：2006-10-26

  Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  所选化合物对于预防和治疗HGF介导的疾病等具有有效性。本发明涵盖了新颖的化合物、类似物、前药和其药学上可接受的盐，以及用于预防和治疗涉及癌症等疾病和其他疾病或状况的药物组合物和方法。该发明还涉及制备此类化合物的过程，以及在此类过程中有用的中间体。
• Poly(ester-amide) capable of forming an anisotropic melt phase derived from 6-hydroxy-2-naphthoic acid, dicarboxylic acid and aromatic monomer capable of forming an amide linkage
  申请人：CELANESE CORPORATION

  公开号：EP0053940A1

  公开（公告）日：1982-06-16

  A melt processable poly(ester-amide) which is capable of forming an anisotropic melt phase is provided. The poly(ester-amide) of the present invention consists essentially of the recurring units (a) 6-oxy-2-naphthoyl moiety, (b) aryl dicarboxyl moiety or trans-1,4-dicarboxycyclohexane moiety, (c) an aromatic moiety capable of forming an amide linkage in the polymer and (d) optionally, dioxyaryl moiety in the proportions indicated. Preferably, the aromatic moiety capable of forming an amide linkage is p-aminophenol or p-phenylene-diamine. The resulting poly(ester-amide) exhibits a melting temperature below 400°C., preferably below 350°C. The poly(ester-amide) of the present invention is preferably formed by a melt polymerisation technique.

  本发明提供了一种能够形成各向异性熔相的可熔融加工聚（酯-酰胺）。本发明的聚（酯-酰胺）主要由以下递归单元组成：(a) 6-氧-2-萘甲酰分子；(b) 芳基二羧基分子或反式-1,4-二羧基环己烷分子；(c) 能在聚合物中形成酰胺键的芳基分子；(d) 可选的二氧基芳基分子，其比例如图所示。能形成酰胺键的芳香基团最好是对氨基苯酚或对苯二胺。所得聚酯酰胺的熔点低于 400°C，最好低于 350°C。本发明的聚（酯-酰胺）最好通过熔融聚合技术形成。
• Polyester of 6-hydroxy-4-naphthoic acid, 4-hydroxy benzoic acid, 1-4-cyclohexanedicarboxylic acid, and aromatic diol capable of readily undergoing melt processing to form articles possessing high impact properties
  申请人：CELANESE CORPORATION

  公开号：EP0071447A1

  公开（公告）日：1983-02-09

  A novel polyester is provided which has been found to exhibit an optically anisotropic melt phase which enables it readily to undergo melt processing to form quality moulded articles possessing unusually high impact properties, etc. The polyester of the present invention contains recurring 6-oxy-2-naphthoyl, 4-oxybenzoyl and 1,4-dicarboxycyclohexane moieties in addition to a moiety derived from an aromatic diol in the proportions indicated. The hydrogen atoms present upon the aromatic rings optionally may be at least partially substituted (as described). The polyester is capable of forming the desired anisotropic melt at a temperature below approximately 350°C., and in a particularly preferred embodiment at a temperature below approximately 320°C.

  本发明提供了一种新型聚酯，该聚酯具有光学各向异性熔融相，使其能够很容易地进行熔融加工，以形成具有非同寻常的高冲击性能等的优质模塑制品。 本发明的聚酯除了含有一个由芳香族二元醇衍生的分子外，还含有重复出现的 6-氧-2-萘甲酰基、4-氧-苯甲酰基和 1,4-二羧基环己烷分子，其比例如图所示。 芳香环上的氢原子可选择至少部分取代（如所述）。 该聚酯能够在低于约 350°C 的温度下形成所需的各向异性熔体，在一个特别优选的实施方案中，其温度低于约 320°C。
• Polyester of 6-hydroxy-2-naphthoic acid, aromatic diol and 1,4-cyclohexanedicarboxylic acid capable of undergoing melt processing
  申请人：CELANESE CORPORATION

  公开号：EP0049615A1

  公开（公告）日：1982-04-14

  A novel polyester is provided which has been found to exhibit an optically anisotropic melt phase which enables it readily to undergo melt processing to form quality fibres, films, moulded articles, etc. The polyester of the present invention contains recurring 6-oxy-2-naphthoyl moieties in addition to moieties derived from at least one aromatic diol and trans-1,4-cyciohexanedicarboxylic acid in the proportions indicated. The hydrogen atoms present upon the rings of these moieties optionally may be at least partially substituted (as described). The polyester is capable of forming the desired anisotropic melt at a temperature below approximately 350=C., and in a particularly preferred embodiment at a temperature below approximately 320°C.

  本发明提供了一种新型聚酯，该聚酯显示出光学各向异性熔融相，使其易于进行熔融加工，从而形成优质纤维、薄膜、模塑制品等。本发明的聚酯除了含有重复出现的 6-氧-2-萘甲酰基外，还含有至少一种芳香族二元醇和反式-1,4-环己烷二羧酸衍生的基团，其比例如图所示。这些分子环上的氢原子可选择至少部分取代（如上所述）。聚酯能够在低于约 350°C 的温度下形成所需的各向异性熔体，在一个特别优选的实施方案中，其温度低于约 320°C。