(+/-)-3-(α-amino-benzyl)-pentan-3-ol | 104743-30-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (+/-)-3-(α-amino-benzyl)-pentan-3-ol
• 英文别名: (+/-)-3-(amino-phenyl-methyl)-pentan-3-ol；3-[Amino(phenyl)methyl]pentan-3-ol
• CAS: 104743-30-8
• 化学式: C₁₂H₁₉NO
• 分子量: 193.289
• InChiKey: KKYIWWHRFSKYIS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Monophosphine compound, transition metal complex thereof and production method of optically active compound using the complex as asymmetric catalyst
  申请人：Carreira M. Erick

  公开号：US20050277772A1

  公开（公告）日：2005-12-15

  The present invention provides a compound represented by the formula (I): wherein ring A is void or a benzene ring optionally having substituent(s), R 1 and R 2 are each independently a phenyl group optionally having substituent(s), a cyclohexyl group and the like, R 3 and R 4 are each independently a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group and the like, and X is a residue represented by —OR 5 or —NHR 6 wherein R 5 and R 6 are a lower alkyl group optionally having substituent(s), an aralkyl group optionally having substituent(s) and the like, a asymmetric transition metal complex containing the compound as a ligand and a production method of optically active compound using the complex as an asymmetric catalyst.

  本发明提供了一种由以下式（I）表示的化合物： 其中环A为空或是一个苯环，可选地具有取代基，R1和R2分别独立地是一个苯基，可选地具有取代基，一个环己基等，R3和R4分别独立地是一个氢原子，一个卤原子，一个低碳基团，一个低碳氧基团等，X是由—OR5或—NHR6表示的残基，其中R5和R6是一个低碳基团，可选地具有取代基，一个芳基烷基团，可选地具有取代基等，一种含有该化合物作为配体的不对称过渡金属配合物以及使用该配合物作为不对称催化剂的光学活性化合物的生产方法。
• Method of preparing amine stereoisomers
  申请人：Han Zhengxu

  公开号：US20050165240A1

  公开（公告）日：2005-07-28

  This invention provides a method of preparing amine stereoisomers, which comprises stereoselectively reducing a sulfinylimine that bears on the sulfinyl group a residue of an alcohol, thiol or amine, or reacting a sulfinylimine stereoisomer that bears on the sulfinyl group a residue of an alcohol, thiol or amine with a source of a nucleophile, to afford a sulfinylamine stereoisomer, followed by contacting the sulfinylamine stereoisomer with a reagent suitable for the cleavage of a sulfur-nitrogen bond, to afford an amine stereoisomer. It also provides novel intermediates useful in the method, and the use of certain of the intermediates in the preparation of sulfoxide and sulfinylamine stereoisomers.

  本发明提供了一种制备胺立体异构体的方法，包括选择性地还原带有醇、硫醇或胺残基的亚磺酰亚胺，或将带有醇、硫醇或胺残基的亚磺酰亚胺立体异构体与核苷酸源反应，得到亚磺酰胺立体异构体，然后将亚磺酰胺立体异构体与适用于断裂硫-氮键的试剂接触，得到胺立体异构体。本发明还提供了在该方法中有用的新型中间体，以及某些中间体在制备亚砜和亚磺酰胺立体异构体中的使用。
• Method of Preparing Amine Stereoisomers
  申请人：Han Zhengxu

  公开号：US20080214870A1

  公开（公告）日：2008-09-04

  This invention provides intermediates useful in a method of preparing amine stereoisomers. It also provides a method of preparing sulfoxide and sulfinylamine stereoisomers using certain of the intermediates.

  这项发明提供了在制备胺立体异构体的方法中有用的中间体。它还提供了一种使用某些中间体制备亚砜和亚砜胺立体异构体的方法。
• Copper complexes of optically active bisoxazolines as enantioselective catalysts in cyclopropanation reactions
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP0895992A2

  公开（公告）日：1999-02-10

  An optically active bisoxazoline compound of the formula [I]: wherein R1 represents an alkyl group, cycloalkyl group, aralkyl group, phenyl group which may be substituted or an alkoxy group and two geminal alkyl groups may be joined together to form a cyclic structure;    R2 represents an alkyl group , cycloalkyl group, aralkyl group or phenyl group which may be substituted;    R3 represents a hydrogen atom, (C2-C4)alkyl group or cycloalkyl group; and    the asterisk * represents an asymmetric carbon atom.

  式[I]的光学活性双噁唑啉化合物： 其中 R1 代表烷基、环烷基、芳基、可被取代的苯基或烷氧基，两个烷基可连接在一起形成环状结构； R2 代表烷基、环烷基、芳基或可被取代的苯基； R3 代表氢原子、(C2-C4)烷基或环烷基；以及 星号 * 代表不对称碳原子。
• Transition metal compounds, catalyst components and catalysts for olefin polymerization, and process for producing olefinic polymers
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP0942010A1

  公开（公告）日：1999-09-15

  A transition metal compound represented by the general formula (2) or (3) described below, a catalyst component for olefin polymerization comprising said transition metal compound, a catalyst component for olefin polymerization using said transition metal compound and (C) and/or (D) described below, and a process for producing an olefinic polymer wherein olefins are homopolymerized or olefins are copolymerized with other olefins and/or other polymerizable unsaturated compound using said catalyst for olefin polymerization. (C): A specific aluminum compound (D): A specific boron compound

  一种由下述通式(2)或(3)表示的过渡金属化合物，一种包含所述过渡金属化合物的烯烃聚合催化剂组分，一种使用所述过渡金属化合物和下述(C)和/或(D)的烯烃聚合催化剂组分，以及一种生产烯烃聚合物的工艺，其中使用所述烯烃聚合催化剂使烯烃均聚或使烯烃与其他烯烃和/或其他可聚合的不饱和化合物共聚。 (C):一种特定的铝化合物 (D)：一种特定的硼化合物