4-Hydroxypentyl(trimethyl)azanium

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-Hydroxypentyl(trimethyl)azanium
• 化学式: C8H20NO+
• 分子量: 146.25
• InChiKey: HSBSNRZAOXKTSK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Use of Functionalized Onium Salts for Peptide Synthesis
  申请人：Vaultier Michel

  公开号：US20100292439A1

  公开（公告）日：2010-11-18

  A subject of the invention is the use of a salt with a dedicated task of formula (I): A + -L-R—OY, X − as soluble support for peptide synthesis, in which: X − represents a functional or non-functional anion, Y represents either a hydrogen atom, or a —COOR 1 group, R 1 representing in particular an alkyl group comprising 1 to 20 carbon atoms, A + represents a cationic entity, L represents an arm, in particular an alkyl group of 3 to 20 carbon atoms, R represents in particular a group of formula —C(R a )(R b )—, R a and R b representing independently of one another in particular a hydrogen or an alkyl group, comprising 1 to 20 carbon atoms.

  本发明涉及使用具有专用任务的盐的一种，其化学式为(I): A+-L-R—OY，X−作为肽合成的可溶性支持，其中：X−代表功能性或非功能性阴离子，Y代表氢原子或—COOR1基团，其中R1特指含有1至20个碳原子的烷基基团，A+代表阳离子实体，L代表一个臂，特指含有3至20个碳原子的烷基基团，R特指特定的—C(Ra)(Rb)—基团，Ra和Rb分别独立地代表氢或烷基基团，包括1至20个碳原子。
• IONTOPHORESIS DELIVERY OF CATIONIC PRODRUGS FOR TOPICAL TREATMENT OF MUSCULOSKELETAL OR SKIN DISEASES
  申请人：Yan Guang

  公开号：US20150297718A1

  公开（公告）日：2015-10-22

  The present invention provides a method for topical delivery of pharmacologically active chemicals into local tissues (skin, subcutaneous, muscle and joint tissues) via the administration of their specially designed cationic prodrugs with anode iontophoresis. The pharmacologically active chemicals are either negatively charged or neutral under the physiologic pH, which are not suitable to be delivered with the anode iontophoresis. The cationic prodrugs of such pharmacologically active chemicals are suitable for anode iontophoresis for improving delivery efficiency of these drugs into the local tissues. The cationic prodrugs can also be used in co-delivery with other cationic drugs such as vasoconstrictors or local anesthetic agents by iontophoresis for treatment of disorders in the local tissues. The anode iontophoresis delivery of the specially designed cationic prodrugs can provide higher drug concentrations in the local tissues, which can be used for better topical treatment of musculoskeletal diseases or skin diseases.
• [EN] USE OF FUNCTIONALIZED ONIUM SALTS FOR THE SYNTHESIS OF PEPTIDES<br/>[FR] UTILISATION DE SELS D'ONIUM FONCTIONNALISÉS POUR LA SYNTHÈSE DE PEPTIDES
  申请人：CENTRE NAT RECH SCIENT

  公开号：WO2008003836A1

  公开（公告）日：2008-01-10

  [EN] The invention provides for the use of a special-purpose salt of formula (I): A⁺-L-R-OY, X^- as a soluble support for the synthesis of peptides, in which: X^- represents a functional or non-functional anion, Y represents either a hydrogen atom or a group -COOR₁, where R₁ represents in particular an alkyl group containing 1 to 20 carbon atoms, A⁺ represents a cationic entity, L represents a linking arm, in particular an alkyl group of 3 to 20 carbon atoms, R represents in particular a group of formula -C(R_a)(R_b)-, where R_a and R_b independently of one another represent in particular a hydrogen or an alkyl group containing 1 to 20 carbon atoms.
  [FR] L'invention a pour objet l'utilisation d'un sel à tâche dédiée de formule (I) : A⁺-L-R-OY, X^- comme support soluble pour la synthèse de peptides, dans laquelle : X^- représente un anion, fonctionnel ou non, Y représente soit un atome d'hydrogène, soit un groupe -COOR₁, R₁ représentant notamment un groupe alkyle comprenant de 1 à 20 atomes de carbone, A⁺ représente une entité cationique, L représente un bras, notamment un groupe alkyle de 3 à 20 atomes de carbone, R représente notamment un groupe de formule -C(R_a)(R_b)-, R_a et R_b représentant indépendamment l'un de l'autre notamment un hydrogène ou un groupe alkyle, comprenant de 1 à 20 atomes de carbone.