2-[[1-(Hydroxymethyl)cyclopentyl]amino]acetaldehyde

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-[[1-(Hydroxymethyl)cyclopentyl]amino]acetaldehyde
• 英文别名: 2-[[1-(hydroxymethyl)cyclopentyl]amino]acetaldehyde
• 化学式: C₈H₁₅NO₂
• 分子量: 157.21
• InChiKey: SUWMPBOTCXLVFT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] PYRROLO[2,3-B]PYRAZINE COMPOUNDS AS CCCDNA INHIBITORS FOR THE TREATMENT OF HEPATITIS B VIRUS (HBV) INFECTION<br/>[FR] COMPOSÉS DE PYRROLO[2,3-B]PYRAZINE EN TANT QU'INHIBITEURS DE L'ADNCCC POUR LE TRAITEMENT D'UNE INFECTION PAR LE VIRUS DE L'HÉPATITE B (VHB)
  申请人：HOFFMANN LA ROCHE

  公开号：WO2019110589A1

  公开（公告）日：2019-06-13

  The present invention relates to novel therapeutic agents against hepatitis B virus (HBV) infection, particularly inhibitors of viral covalently closed circular DNA (cccDNA) which is the key barrier for HBV cure. Accordingly, the invention provides the pyrrolo[2,3-b]pyrazine compounds of formula (I), as described and defined herein, for use in the treatment of HBV infection. The compounds provided herein are highly potent against HBV infection and enable an improved therapy, particularly of chronic HBV infection and HBV rebound. The present invention further relates to a novel screening assay for the identification of therapeutic agents against HBV infection, particularly cccDNA inhibitors, which is performed in hepatocyte-like cells that recapitulate the complete HBV life cycle following infection with patient-derived HBV.