4-amino-6-ethyl-8-methyl-1H-quinazolin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-amino-6-ethyl-8-methyl-1H-quinazolin-2-one
• 化学式: C₁₁H₁₃N₃O
• 分子量: 203.24
• InChiKey: HTYOMBSEPSFCPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  67.5
• 氢给体数：
  2
• 氢受体数：
  1

文献信息

• OLIGONUCLEOTIDES FOR TREATING EXPANDED REPEAT DISEASES
  申请人：Sarepta Therapeutics, Inc.

  公开号：EP2785729B1

  公开（公告）日：2020-11-04
• [EN] OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF<br/>[FR] COMPOSITIONS D'OLIGONUCLÉOTIDES ET PROCÉDÉS ASSOCIÉS
  申请人：WAVE LIFE SCIENCES LTD

  公开号：WO2017062862A2

  公开（公告）日：2017-04-13

  Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide altered splicing of a transcript. In some embodiments, provided oligonucleotide compositions have low toxicity. In some embodiments, provided oligonucleotide compositions provide improved protein binding profiles. In some embodiments, provided oligonucleotide compositions have improved delivery. In some embodiments, provided oligonucleotide compositions have improved uptake. In some embodiments, the present disclosure provides methods for treatment of diseases using provided oligonucleotide compositions.
• [EN] COMPOSITIONS COMPRISING EXON SKIPPING OLIGONUCLEOTIDE CONJUGATES FOR TREATING MUSCULAR DYSTROPHY<br/>[FR] COMPOSITIONS COMPRENANT DES CONJUGUÉS D'OLIGONUCLÉOTIDES À SAUT D'EXON POUR LE TRAITEMENT DE LA DYSTROPHIE MUSCULAIRE
  申请人：[en]SAREPTA THERAPEUTICS, INC.

  公开号：WO2022140535A1

  公开（公告）日：2022-06-30

  Composition comprising: (a) an antisense oligonucleotide conjugate comprising a cell penetrating peptide covalently attached to a nucleic acid analog, or a pharmaceutically acceptable salt thereof, wherein the cell penetrating peptide includes at least two positively charged amino acids; (b) one or more surfactants; (c) one or more sugars; and (d) one or more buffering agents are provided herein.