(8S,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (8S,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
• 化学式: C₂₂H₂₉FO₅
• 分子量: 392.5
• InChiKey: UREBDLICKHMUKA-ZCWWIVCJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  28
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  94.8
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Modulators of the glucocorticoid receptor
  申请人：Pfizer Inc.

  公开号：US20040138262A1

  公开（公告）日：2004-07-15

  The present invention provides compounds of the formula 1 wherein A is of the formula 2 and X, Y, n, R 1 -R 25 are as described in the specification which are modulators of the glucocorticoid receptor and are thus useful for the treatment of animals requiring glucocorticoid receptor agonist therapy. Glucocorticoid receptor modulators are useful in the treatment of certain inflammatory conditions.

  本发明提供了一些化合物，其化学式为1，其中A的化学式为2，X、Y、n、R1-R25如说明书所述，这些化合物是糖皮质激素受体调节剂，因此对需要糖皮质激素受体激动剂治疗的动物有用。糖皮质激素受体调节剂在治疗某些炎症病症方面是有用的。
• Modulators of the Glucocorticoid Receptor
  申请人：Chantigny A. Yves

  公开号：US20060247264A1

  公开（公告）日：2006-11-02

  The present invention provides compounds of the formula wherein A is of the formula and X, Y, n, R 1 —R 25 are as described in the specification which are modulators of the glucocorticoid receptor and are thus useful for the treatment of animals requiring glucocorticoid receptor agonist therapy. Glucocorticoid receptor modulators are useful in the treatment of certain inflammatory conditions.

  本发明提供了公式的化合物，其中A的公式为，X、Y、n、R1-R25如规范所述，它们是糖皮质激素受体的调节剂，因此对需要糖皮质激素受体激动剂治疗的动物有用。糖皮质激素受体调节剂在治疗某些炎症性疾病方面是有用的。
• Glucocorticoid receptor modulators
  申请人：Dow L. Robert

  公开号：US20070117805A1

  公开（公告）日：2007-05-24

  The present invention provides non-steroidal compounds of formula I which are selective modulators (i.e., agonists and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides pharmaceutical compositions containing these compounds and methods for using these compounds to treat animals requiring glucocorticoid receptor agonist or antagonist therapy. Glucocorticoid receptor modulators are useful to the diseases, such as obesity, diabetes, inflammation and others as described below. The present invention also provides intermediates and processes for preparing these compounds.

  本发明提供公式I的非甾体化合物，它们是类固醇受体的选择性调节剂（即激动剂和拮抗剂），具体地，是糖皮质激素受体。本发明还提供含有这些化合物的药物组合物，并使用这些化合物治疗需要糖皮质激素受体激动剂或拮抗剂治疗的动物的方法。糖皮质激素受体调节剂对于肥胖症、糖尿病、炎症等疾病是有用的，如下所述。本发明还提供制备这些化合物的中间体和方法。
• Compositions for nasal delivery
  申请人：Touitou Elka

  公开号：US20090047234A1

  公开（公告）日：2009-02-19

  The present invention concerns a method of administering at least one active pharmaceutical agent to a patient in need thereof, which method comprises the intranasal administration of a composition comprising a therapeutically effective amount of this agent, phospholipids, one or more C2-C4 alcohols and water, wherein the concentrations of the phospholipids and the one or more alcohols in the composition are in the ranges of 0.2 to 10% and 12 to 30% by weight, respectively, with the water content of said composition being not less than 30% by weight, the phospholipids forming vesicles in said composition. Further are disclosed pharmaceutical compositions and combinations suitable for intranasal delivery.

  本发明涉及一种给需要的患者施用至少一种活性药物的方法，该方法包括经鼻给药一种组合物，该组合物包括治疗有效量的该药物、磷脂、一种或多种C2-C4醇和水，其中该组合物中磷脂和一种或多种醇的浓度分别在0.2%至10%和12%至30%之间，该组合物的水含量不少于30%的重量，磷脂在该组合物中形成泡腔。此外，还公开了适用于经鼻给药的药物组合物和组合。
• METHOD OF TREATING A PATHOLOGICAL SYNDROME
  申请人：Epshtein Oleg Iliich

  公开号：US20160229914A1

  公开（公告）日：2016-08-11

  A method of treating disorder or condition that relates to intracellular signal transmission of a neurotransmitter, comprising administration of an homeopathically potentized form of antibodies to an antigen, which antigen is a molecule capable of effecting the intracellular signal transmission of a neuroreceptor, in particular dopamine or serotonin.

  一种治疗与神经递质的细胞内信号传递相关的疾病或症状的方法，包括给予一种高度稀释的抗原抗体制剂，该抗原是一种能够影响神经受体的细胞内信号传递的分子，特别是多巴胺或血清素。