1-methyl-5-phenethyl-biguanide | 102656-03-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-methyl-5-phenethyl-biguanide
• 英文别名: 1-Methyl-5-phenaethyl-biguanid；1-(N'-methylcarbamimidoyl)-2-(2-phenylethyl)guanidine
• CAS: 102656-03-1
• 化学式: C₁₁H₁₇N₅
• 分子量: 219.289
• InChiKey: GHBQKLBYJGKNGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  88.8
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-[(2-phenylethyl)]-3-cyanoguanidine 、 盐酸甲胺 生成 1-methyl-5-phenethyl-biguanide
  参考文献：
  名称：

  Hypoglycemic Agents. IV.^1—3 N¹,N⁵-Alkyl- and Aralkylbiguanides

  摘要：

  DOI：

  10.1021/ja01526a047

文献信息

• Biguanide compositions and methods of treating metabolic disorders
  申请人：Elcelyx Therapeutics, Inc.

  公开号：US10028923B2

  公开（公告）日：2018-07-24

  Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.

  本文提供了通过施用包含双胍类或相关杂环化合物（如二甲双胍）的组合物来治疗某些疾病（包括糖尿病、肥胖症和其他代谢性疾病、失调或病症）的方法。本文还提供了双胍类或相关杂环化合物组合物及其用于本发明方法的制备方法。本文还提供了包含二甲双胍及其盐类的组合物和使用方法。
• Biguanide derivative, a preparation method thereof, and a pharmaceutical composition containing the biguanide derivative as an active ingredient
  申请人：Immunomet Therapeutics Inc.

  公开号：US10376480B2

  公开（公告）日：2019-08-13

  A biguanide derivative compound with N1-N5 substitution, which is represented by Formula 1, or a pharmaceutically acceptable salt thereof, a method of preparing the same, and a pharmaceutical composition containing the same as an active ingredient are provided. The biguanide derivative may exhibit excellent effect on activation of AMPKα and inhibition of cancer cell proliferation in a low dose, compared to conventional drugs, and thus, may be useful to treat diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovarian syndrome, metabolic syndrome, cancer, etc.

  本发明提供了一种由式 1 表示的具有 N1-N5 取代的双胍衍生物化合物或其药学上可接受的盐、其制备方法以及以其为活性成分的药物组合物。与传统药物相比，该双胍衍生物可在低剂量下表现出良好的激活 AMPKα 和抑制癌细胞增殖的效果，因此可用于治疗糖尿病、肥胖症、高脂血症、高胆固醇血症、脂肪肝、冠心病、骨质疏松症、多囊卵巢综合征、代谢综合征、癌症等。
• BIGUANIDE COMPOSITIONS AND METHODS OF TREATING METABOLIC DISORDERS
  申请人：Anji Pharma (US) LLC

  公开号：EP2800561B1

  公开（公告）日：2020-08-19
• Biguanide Compositions and Methods of Treating Metabolic Disorders
  申请人：Baron Alain D.

  公开号：US20130095140A1

  公开（公告）日：2013-04-18

  Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.
• US20140341986A1
  申请人：——

  公开号：US20140341986A1

  公开（公告）日：2014-11-20