4-phenylfuroic acid | 86471-28-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 英文名称: 4-phenylfuroic acid
• 英文别名: 4-phenylfuran-2-carboxylic acid
• CAS: 86471-28-5
• 化学式: C₁₁H₈O₃
• 分子量: 188.183
• InChiKey: KBGLLDCBYBKUIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  furan-3-carbohydrazide 、 4-phenylfuroic acid 在 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以32%的产率得到N'-(furan-3-carbonyl)-4-phenylfuran-2-carbohydrazide
  参考文献：
  名称：

  Discovery of furan-2-carbohydrazides as orally active glucagon receptor antagonists

  摘要：

  Furan-2-carbohydrazides were found as orally active glucagon receptor antagonists. Starting from the hit compound 5, we successfully determined the structure activity relationships of a series of derivatives obtained by modifying the acidity of the phenol. We identified the ortho-nitrophenol as a good scaffold for glucagon receptor inhibitory activity. Our efforts have led to the discovery of compound 7l as a potent glucagon receptor antagonist with good bioavailability and satisfactory long half-life.

  DOI：

  10.1016/j.bmcl.2014.07.025
• 作为产物：
  描述：

  ethyl (2R,3R)-2-methoxy-3-phenyl-2,3-dihydrofuran-5-carboxylate 生成 4-phenylfuroic acid
  参考文献：
  名称：

  ALONSO, M. E.;JANO, P.;HERNANDEZ, M. I.;GREENBERG, R. S.;WENKERT, E., J. ORG. CHEM., 1983, 48, N 18, 3047-3050

  摘要：

  DOI：

文献信息

• Cyclic derivatives as modulators of chemokine receptor activity
  申请人：Carter H. Percy

  公开号：US20050054627A1

  公开（公告）日：2005-03-10

  The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the treatment of rheumatoid arthritis, multiple sclerosis, atherosclerosis and asthma.

  当前申请描述了MCP-1的调节剂，其化学公式为(I):或其药用可接受的盐形式，用于治疗类风湿性关节炎、多发性硬化症、动脉粥样硬化和哮喘。
• Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity
  申请人：Carter H. Percy

  公开号：US20050054626A1

  公开（公告）日：2005-03-10

  The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis, artherosclerosis, and rheumatoid arthritis.

  本申请描述了MCP-1的调节剂，化学式为(I)：或其药用可接受的盐形式，用于预防哮喘、多发性硬化症、动脉粥样硬化和类风湿性关节炎。
• Hygromycin derivatives
  申请人：Pfizer Inc

  公开号：US06313100B1

  公开（公告）日：2001-11-06

  This invention relates to compounds of the formula and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1 and R2 are as defined herein. The compounds of formula 1 are antibacterial and antiprotozoal agents that may be used to treat various bacterial and protozoal infections and disorders related to such infections. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating bacterial and protozoal infections by administering the compounds of formula 1.

  本发明涉及公式化合物及其药学可接受的盐、前药和溶剂化物，其中R1和R2的定义如本文所述。公式1的化合物是抗菌和抗原虫剂，可用于治疗各种细菌和原虫感染及与此类感染相关的疾病。本发明还涉及含有公式1化合物的制药组合物以及通过给予公式1化合物治疗细菌和原虫感染的方法。
• CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
  申请人：Carter Percy H.

  公开号：US20090124668A1

  公开（公告）日：2009-05-14

  The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the treatment of rheumatoid arthritis, multiple sclerosis, atherosclerosis and asthma.

  本申请描述了 MCP-1 的调节剂，其化学式为 (I) 或其药学上可接受的盐形式，适用于治疗类风湿性关节炎、多发性硬化症、动脉粥样硬化和哮喘。
• Method of preparing a composition containing hygromycin A and epi-hygromycin
  申请人：Pfizer Products Inc.

  公开号：EP1369490A1

  公开（公告）日：2003-12-10

  A method of preparing a composition containing hygromycin A and epi-hygromycin, wherein the ratio of hygromycin A to epi-hygromycin is at least 10:1, which comprises fermenting Streptomyces hygroscopicus in media having a pH less than 6.9 at a temeperature ranging from 25°C to 35°C.

  一种制备含百日咳霉素 A 和表-百日咳霉素的组合物的方法，其中百日咳霉素 A 与表-百日咳霉素的比例至少为 10:1，该方法包括在 pH 值小于 6.9 的培养基中，在 25°C 至 35°C 的温度范围内发酵吸湿链霉菌。