1-(Aminomethyl)cyclooctan-1-amine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-(Aminomethyl)cyclooctan-1-amine
• 化学式: C₉H₂₀N₂
• 分子量: 156.27
• InChiKey: JDPOGMLCKVQEPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Antitumor platinum complexes
  申请人：Bristol-Myers Squibb Company

  公开号：EP0155705A2

  公开（公告）日：1985-09-25

  Novel platinum (II) complexes of 1,2-diamino- cyclohexane, 1-aminomethylcyclooctylamine and 1,2-diamino-2,4-dimethylpentane are provided. Such complexes are of use in inhibiting the growth of certain mammalian tumors.

  提供了 1,2-二氨基环己烷、1-氨基甲基环辛胺和 1,2-二氨基-2,4-二甲基戊烷的新型铂 (II) 复合物。这些复合物可用于抑制某些哺乳动物肿瘤的生长。
• NOVEL COMPLEXES, PROCESS FOR THEIR PREPARATION, AND MEDICINAL USE OF THEM
  申请人：KURARAY CO., LTD.

  公开号：EP0270682A1

  公开（公告）日：1988-06-15

  Pullulans having active sites formed by sulfation, phosPhorylation, sulfonation or carboxylation or their pharmacologically acceptable salts, wherein one hydrogen atom of the active sites represented by formula (I), partially sub- stituted by a group represented by the general formula (II), (wherein L1 and L2 each represents amine or unidentate amine or when taken together, represent bidentate amine. and Y represents an anionic ligand) and/or two hydrogen atoms or the active sites represented by formula (III) or of two formula (IV) groups bound to the same carbon atom or adjacent carbon atoms are partially substituted by a group represented by the formula (V), (wherein L' and L2 are the name as defined above). These compounds have an onco- static activity and are useful as oncostatic agents. Process for their preparation and their medicinal use are also dis- closed

  具有通过硫化、磷化、磺化或羧化形成的活性位点或其药理学上可接受的盐的普鲁兰 类，其中式(I)所代表的活性位点的一个氢原子部分被通式(II)所代表的基团取代，(其中 L1 和 L2 各自代表胺或非同位胺，或合在一起代表双同位胺。和 Y 代表阴离子配体）和/或两个氢原子或式（III）所代表的活性位点或与同一碳原子或相邻碳原子结合的两个式（IV）基团部分被式（V）所代表的基团取代（其中 L' 和 L2 的名称如上定义）。这些化合物具有抗静电活性，可用作抗静电剂。它们的制备工艺和药用价值也已公开。
• Novel macromolecular complexes, process for producing same and medicinal use of such complexes
  申请人：KURARAY CO., LTD.

  公开号：EP0307827A2

  公开（公告）日：1989-03-22

  A dextran or hydroxyethyl starch derivative having one or more carboxylated active sites resulting from reaction with an aliphatic di-, tri- or tetrabasic acid or a reactive derivative thereof, wherein one hydrogen atom of the qroup of the formula occurring at said active sites is partly substituted by a group of the general formula wherein L' and L2 each independently is ammine or a unidentate ligand amine or combinedly represent a bidentate ligand amine and Y is an anionic ligand, and/or two hydrogen atoms of two groups bound to one and the same carbon atom or to two neighboring carbon atoms as occurring at said active sites are, each independently, partly substituted by a group of the general formula wherein L1 and L2 are as defined above, and a pharmacologically acceptable salt thereof. The above compound has anticancer activity and is useful as anticancer agents.

  一种具有一个或多个羧化活性位点的葡聚糖或羟乙基淀粉衍生物，该活性位点是与脂肪族二元酸、三元酸或四元酸或其活性衍生物反应而形成的，其中出现在所述活性位点的式 q 组的一个氢原子被通式基团部分取代。 在所述活性位点上出现的一个通式基团的氢原子部分被通式基团取代 其中 L'和 L2 各自独立地为胺或单齿配体胺或组合代表双齿配体胺，Y 为阴离子配体，和/或两个基团的两个氢原子 在所述活性位点上出现的与一个相同碳原子或两个相邻碳原子结合的两个基团的两个氢原子各自独立地被通式如下的基团部分取代 其中 L1 和 L2 如上定义，以及其药理学上可接受的盐。 上述化合物具有抗癌活性，可用作抗癌剂。
• PLATINUM (II) COMPLEXES
  申请人：SAGAMI CHEMICAL RESEARCH CENTER

  公开号：EP0386243A1

  公开（公告）日：1990-09-12

  Novel platinum (II) complexes represented by general formula (I), wherein AB represents a bidentate diamine ligand, R1 and R2 independently represent a hydrogen atom or an alkyl group containing 1 to 8 carbon atoms, provided that R1 and R2 do not represent hydrogen atoms at the same time, Ar represents an aryl group, and n represents 0 or 1. The platinum (II) complexes have a strong growth inhibiting action on P-388 mouse leukemia cells and are used as novel substances having an oncostatic activity.

  通式(I)代表的新型铂(II)络合物，其中 AB 代表双齿二胺配体，R1 和 R2 独立地代表氢原子或含有 1 至 8 个碳原子的烷基，但 R1 和 R2 不能同时代表氢原子，Ar 代表芳基，n 代表 0 或 1。铂（II）配合物对 P-388 小鼠白血病细胞有很强的生长抑制作用，可用作具有抗癌活性的新型物质。
• NOVEL PLATINUM (II) COMPLEX AND REMEDY FOR MALIGNANT TUMOR
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP0704453A1

  公开（公告）日：1996-04-03

  A novel platinum complex (II) represented by general formula (A) and a remedy for malignant tumor containing the same as the active ingredient, wherein R₁ represents a C₁-C₃ lower hydrocarbon group; R₂ ad R₃ represent each independently hydrogen or a C₁-C₃ lower hydrocarbon group, or R₂ and R₃ may be combined together to represent -(CH₂)₄- or -(CH₂)₅-; Y and Z represent each independently ammonia or a monodentate amine having a C₁-C₇ hydrocarbon group, or Y and Z may be combined together to represent a didentate diamine having a C₂-C₁₀ hydrocarbon group; and X- represents an inorganic acid anion or an organic carboxylic acid anion. This compound is efficacious against cisplatin-resistant cancer, has a solubility suitable for intravenous administration, is stable in aqueous solution, and has an excellent antitumor activity.

  一种由通式(A)表示的新型铂络合物(II)和一种治疗恶性肿瘤的药物，其中 R₁ 代表 C₁-C₃低级烃基；R₂ 和 R₃ 各自独立地代表氢或 C₁-C₃低级烃基，或 R₂ 和 R₃ 可结合在一起代表-(CH₂)₄- 或-(CH₂)₅-；Y 和 Z 各自独立地代表氨或具有 C₁-C₇烃基的单阳离子胺，或者 Y 和 Z 组合在一起代表具有 C₂-C₁₀ 烃基的双阳离子二胺；以及 X- 代表无机酸阴离子或有机羧酸阴离子。该化合物对顺铂抗性癌症有效，溶解度适合静脉注射，在水溶液中稳定，具有极佳的抗肿瘤活性。