N-[4-[2-[butyl(methyl)amino]ethyl]phenyl]-6-(4-methylphenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-[4-[2-[butyl(methyl)amino]ethyl]phenyl]-6-(4-methylphenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine
• 化学式: C₃₂H₃₆N₄
• 分子量: 476.7
• InChiKey: ZPHBGNRJZBFQMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  36
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  41
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F] ISOQUINOLIN-2-AMINE COMPOUNDS<br/>[FR] COMPOSÉS DE 5,6-DIHYDRO-6-PHÉNYLBENZO[F]ISOQUINOLÉINE-2-AMINES SUBSTITUÉES
  申请人：ARQULE INC

  公开号：WO2010078421A1

  公开（公告）日：2010-07-08

  The present invention relates to substituted 5,6-dihydro-6- phenylbenzo[f]isoquinolin-2-amine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.