5-[(3-Hydroxy-4-methoxyphenyl)methylidene]-2-imino-1,3-thiazolidin-4-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 5-[(3-Hydroxy-4-methoxyphenyl)methylidene]-2-imino-1,3-thiazolidin-4-one
• 英文别名: 5-[(3-hydroxy-4-methoxyphenyl)methylidene]-2-imino-1,3-thiazolidin-4-one
• 化学式: C₁₁H₁₀N₂O₃S
• mdl: MFCD02377030
• 分子量: 250.28
• InChiKey: WCHCAGWRYJMMPY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• 4-oxo-4,5-dihydrothiazole derivative, preparation method and use thereof
  申请人：Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

  公开号：US10611742B2

  公开（公告）日：2020-04-07

  The present invention relates to a compound represented by Formula I, a racemate or optical isomer thereof, or a pharmaceutically acceptable salt, a solvate or a hydrate thereof, a pharmaceutical composition comprising the compound, and a use thereof in the manufacture of a medicament for preventing and/or treating a disease or disorder associated with a viral infection.

  本发明涉及一种由式 I 代表的化合物、其外消旋物或光学异构体、或其药学上可接受的盐、溶液或水合物、包含该化合物的药物组合物，以及其在制造预防和/或治疗与病毒感染有关的疾病或紊乱的药物中的用途。
• 4-OXO-4,5-DIHYDROTHIAZOLE DERIVATIVE, PREPARATION METHOD AND USE THEREOF
  申请人：Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

  公开号：EP3381910B1

  公开（公告）日：2021-12-22
• 4-Oxo-4,5-Dihydrothiazole Derivative, Preparation Method and Use Thereof
  申请人：Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

  公开号：US20180370928A1

  公开（公告）日：2018-12-27

  The present invention relates to a compound represented by Formula I, a racemate or optical isomer thereof, or a pharmaceutically acceptable salt, a solvate or a hydrate thereof, a pharmaceutical composition comprising the compound, and a use thereof in the manufacture of a medicament for preventing and/or treating a disease or disorder associated with a viral infection.