12-amino n-dodecanitrile | 26437-41-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 12-amino n-dodecanitrile
• 英文别名: ω-Aminolauronitril；12-aminododecanenitrile；1-Amino-11-cyanoundecane
• CAS: 26437-41-2
• 化学式: C₁₂H₂₄N₂
• 分子量: 196.336
• InChiKey: BVJKISUCBKDPOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  14
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  12-amino n-dodecanitrile 在 sodium hydroxide 作用下， 以 正丁醇 为溶剂， 100.0 ℃ 、2.0 MPa 条件下， 生成 1,12-二氨基十二烷
  参考文献：
  名称：

  一种从氨基腈类有机物制备有机二胺的方法

  摘要：

  本发明提供一种从氨基腈类有机物制备有机二胺的方法，所述方法包括如下步骤：(1)在催化剂作用下，氨基腈类有机物和氢气在溶剂中进行反应，得到含有机二胺的反应后料；(2)所述反应后料经精制，得到粗有机二胺；(3)所述粗有机二胺经吸附提纯，得到提纯的有机二胺。所述方法通过采用氨基腈类有机物和氢气反应，反应选择性和转化率高，而且后续通过精制和吸附提纯相组合的提纯方式，能够得到高纯的有机二胺产品。

  公开号：

  CN113461539A

文献信息

• Process for cyclizing hydrolysis of an aminonitrile compound to a lactam
  申请人：——

  公开号：US20040116691A1

  公开（公告）日：2004-06-17

  The invention pertains to a process for cyclizing hydrolysis of an aminonitrile compound to a lactam in the presence of a catalyst. It relates more particularly to a process for cyclizing hydrolysis of an aminonitrile compound in the presence of a solid catalyst of clay type. The invention applies particularly to the preparation of &egr;-caprolactam by cyclizing hydrolysis of aminocapronitrile.

  本发明涉及在催化剂存在下，通过氨基腈化合物的水解缩环反应制备内酰胺的方法。更具体地，本发明涉及在粘土类固体催化剂存在下，通过氨基腈化合物的水解缩环反应制备内酰胺的方法。本发明特别适用于通过氨基己腈的水解缩环反应制备ε-己内酰胺。
• Method for reducing the content of an unsaturated amine in a mixture containing an amine and a nitrile
  申请人：——

  公开号：US20040030174A1

  公开（公告）日：2004-02-12

  A process is provided for reducing the content of a monounsaturated aliphatic amine (III) in a mixture (IV) containing an aminonitrile (I) or a diamine (II), or mixtures thereof, and the amine (III), wherein a) the mixture (IV) is reacted with an anionic nucleophile (V), which contains a nucleophilic atom selected from the group comprising oxygen, nitrogen and sulfur, which is capable of taking up an H + ion to form an acid with a pK a ranging from 7 to 11, measured in water at 25° C., and which has a relative nucleophilicity, measured in methyl perchlorate/methanol at 25° C., ranging from 3.4 to 4.7 when oxygen is the nucleophilic atom, ranging from 4.5 to 5.8 when nitrogen is the nucleophilic atom, and ranging from 5.5 to 6.8 when sulfur is the nucleophilic atom, in an amount ranging from 0.01 to 10 mol per mole of amine (III) in the mixture (IV), to give a mixture (VI), and b) the aminonitrile (I) or the diamine (II), or mixtures thereof, are distilled from the mixture (VI) at a temperature ranging from 50 to 170° C. and a pressure ranging from 0.5 to 100 kPa.

  提供了一种方法来降低含有单不饱和脂肪胺(III)的混合物(IV)中的含量，该混合物包含氨基腈(I)或二胺(II)或其混合物和胺(III)，其中a)混合物(IV)与一种阴离子亲核试剂(V)反应，其包含从氧、氮和硫的群组中选择的能够吸收H+离子形成具有在25℃时在水中测得的pKa在7到11之间的酸的亲核原子，并且具有相对亲核性，其在25℃时在甲基高氯酸酯/甲醇中测量，当氧是亲核原子时，范围从3.4到4.7，当氮是亲核原子时，范围从4.5到5.8，当硫是亲核原子时，范围从5.5到6.8，其量为0.01到10摩尔/摩尔胺(III)的混合物(IV)中，以给出混合物(VI)，并且b)氨基腈(I)或二胺(II)或其混合物从混合物(VI)中在50到170℃和0.5到100 kPa的压力下蒸馏。
• Purification of aminonitriles or diamines
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0497333A2

  公开（公告）日：1992-08-05

  Separation of an aliphatic aminonitrile or an aliphatic diamine from a mixture containing the corresponding cyclic, aliphatic, mono-unsaturated amine by adding caustic compound to the mixture and then distilling the aminonitrile or the diamine at a temperature less than 170°C and at a pressure of less than 1 atmosphere.

  将脂肪族氨基腈或脂肪族二胺从含有相应的环状、脂肪族、单不饱和胺的混合物中分离出来，方法是在混合物中加入苛性化合物，然后在温度低于 170°C 和压力低于 1 个大气压的条件下蒸馏氨基腈或二胺。
• Catalyst comprising rutheniumcomplex, and use thereof in hydrogenation of unsaturated substrates, especially organic nitriles
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP1031379A1

  公开（公告）日：2000-08-30

  This invention relates to a catalyst for use in the hydrogenation of unsaturated substrates, especially organic nitriles. The catalyst comprises at least one ruthenium complex having the formula, RuH2L13 (PR3) wherein: PR3 is an organophosphorus ligand; each R is a substituent independently selected from: H, R', OR', OSiR'3, NH2, NHR' and NR'2; each R' is independently selected from: a hydrocarbyl group, and an assembly of at least two hydrocarbyl groups connected by ether or amine linkages; and each L1 is a neutral electron pair donor ligand independently selected from: H2, N2, nitriles, amines, alcohols, ethers, esters, amides, alkenes, alkynes, aldehydes, ketones and imines.

  本发明涉及一种用于不饱和底物，特别是有机腈氢化的催化剂。该催化剂包括至少一种钌络合物，其式为 RuH2L13 (PR3) 其中： PR3 是有机磷配体； 每个 R 是独立选自以下各项的取代基：H、R'、OR'、OSiR'3、NH2、NHR' 和 NR'2 每个 R'独立选自：烃基，以及通过醚或胺连接的至少两个烃基的组合；以及 每个 L1 都是中性电子对供体配体，独立选自：H2、N2、腈、胺、醇、醚、酯、酰胺、烯、炔、醛、酮和亚胺。
• Process for the preparation of ruthenium hydrogenation catalysts and products thereof
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP1090923A1

  公开（公告）日：2001-04-11

  This invention relates to a process for the preparation of ruthenium complexes of the formula RuH2L2(PR3)2 wherein each L is independently H2 or an additional equivalent of PR3, and each R is independently H, a hydrocarbyl group, or an assembly of at least two hydrocarbyl groups connected by ether or amine linkages, comprising contacting a source of ruthenium and PR3 with gaseous hydrogen in the presence of a strong base, a phase transfer catalyst, water and an organic solvent; and the use of certain classes of ruthenium complexes as catalysts in hydrogenation, and reductive hydrolysis processes

  本发明涉及一种制备式 RuH2L2(PR3)2 的钌络合物的工艺，其中每个 L 独立地为 H2 或 PR3 的另一当量，每个 R 独立地为 H、烃基或由醚或胺连接的至少两个烃基的组合，包括在强碱、相转移催化剂、水和有机溶剂存在下使钌源和 PR3 与气态氢接触；在氢化和还原水解过程中使用某些类别的钌络合物作为催化剂