1-Methyl-naphthalin-2-sulfonsaeure | 68487-67-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-Methyl-naphthalin-2-sulfonsaeure
• 英文别名: alpha-methyl-beta-naphthalenesulfonic acid；1-Methyl-2-naphthalenesulfonic acid；1-methylnaphthalene-2-sulfonic acid
• CAS: 68487-67-2
• 化学式: C₁₁H₁₀O₃S
• 分子量: 222.265
• InChiKey: SBMVUWFLYRRTED-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  62.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• TARGETING AN HIV-1 NEF-HOST CELL KINASE COMPLEX
  申请人：University of Pittsburgh - Of the Commonwealth System of Higher Education

  公开号：US20140128388A1

  公开（公告）日：2014-05-08

  Drug candidates for inhibition of HIV-1 replication can target Src family kinases (SFK), such as Hck, that interact with Nef protein of the virus. Compounds characterized by such inhibitory activity were identified via an assay for kinase activity of an SFK in a Nef:SFK complex. Illustrative of inhibitors identified using the kinase assay are various 2,3-diaminoquinaxolines and furo[2,3-d]pyrimidines. The inventive inhibitors were found to arrest HIV-1 viral replication in vitro.

  针对HIV-1复制的药物候选物可以针对Src家族激酶（SFK），例如与病毒的Nef蛋白相互作用的Hck。通过对Nef:SFK复合物中SFK的激酶活性进行测定，鉴定了具有这种抑制活性的化合物。使用激酶测定鉴定的抑制剂的例子包括各种2,3-二氨基喹啉和呋喃[2,3-d]嘧啶。发明的抑制剂被发现可以在体外阻止HIV-1病毒复制。
• Reactive dye composition for cellulose fiber
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0087273A1

  公开（公告）日：1983-08-31

  A reactive dye composition which comprises 20 to 99% by weight of a dye represented by a free acid of formula, and 80 to 1% by weight of an alkylnaphthalenesulfonic acid/formaldehyde condensate having a degree of sulfonation of 50 to 150% and a degree of average condensation of 1.1 to 3.0. The composition is readily soluble in water and aqueous alkali liquors, resistant to coagulation when prepared into a color paste for printing, and is useful for dyeing or printing cellulose fiber materials yellow with a high color yield, particularly by a one-bath pad dyeing method or print method.

  一种活性染料组合物，它包含 20 至 99% （以重量计）由式中游离酸代表的染料，以及 80 至 1% （以重量计）磺化度为 50 至 150%、平均缩合度为 1.1 至 3.0 的烷基萘磺酸/甲醛缩合物。 该组合物易溶于水和水性碱液，在配制成印花用色浆时不易凝固，可用于对黄色纤维素纤维材料进行染色或印花，且得色率高，尤其适用于一浴式轧染法或印花法。
• JP2001019731A
  申请人：——

  公开号：JP2001019731A

  公开（公告）日：2001-01-23
• US4297284A
  申请人：——

  公开号：US4297284A

  公开（公告）日：1981-10-27
• US4482350A
  申请人：——

  公开号：US4482350A

  公开（公告）日：1984-11-13