5-(1,3-Benzothiazol-2-yl)-1,3-benzoxazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑类
• 英文名称: 5-(1,3-Benzothiazol-2-yl)-1,3-benzoxazole
• 英文别名: 5-(1,3-benzothiazol-2-yl)-1,3-benzoxazole
• 化学式: C₁₄H₈N₂OS
• 分子量: 252.29
• InChiKey: RIQGHXSIGXFTGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  67.2
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Method for preparation of alkylated or fluoro, chloro and fluorochloro alkylated compounds by heterogeneous cobalt catalysis
  申请人：Lonza Ltd

  公开号：US10968187B2

  公开（公告）日：2021-04-06

  The invention discloses a method for preparation of alkylated, fluoro alkylated, chloro alkylated and fluorochloro alkylated compounds by a heterogeneous Co-catalysed alkylation or fluoro, chloro and fluorochloro alkylation with alkyl halides, fluoro alkyl halides, chloro alkyl halides or fluorochloro alkyl halides respectively.

  本发明公开了一种通过与烷基卤化物、氟烷基卤化物、氯烷基卤化物或氟氯烷基卤化物分别进行异相共催化烷基化或氟烷基化、氯烷基化和氟氯烷基化来制备烷基化、氟烷基化、氯烷基化和氟氯烷基化化合物的方法。
• Method for Preparation of Alkylated or Fluoro, Chloro and Fluorochloro Alkylated Compounds by Heterogeneous Cobalt Catalysis
  申请人：Lonza Ltd

  公开号：US20200157063A1

  公开（公告）日：2020-05-21

  The invention discloses a method for preparation of alkylated, fluoro alkylated, chloro alkylated and fluorochloro alkylated compounds by a heterogeneous Co-catalysed alkylation or fluoro, chloro and fluorochloro alkylation with alkyl halides, fluoro alkyl halides, chloro alkyl halides or fluorochloro alkyl halides respectively.
• JAK1 SELECTIVE KINASE INHIBITOR
  申请人：DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

  公开号：US20220220096A1

  公开（公告）日：2022-07-14

  Disclosed herein are compounds of Formula (I), and pharmaceutically acceptable salts thereof, that are useful as JAK kinase inhibitors. Also disclosed are pharmaceutical compositions comprising one or more compounds of Formula (I), and methods of using such compounds or compositions to treat respiratory conditions (e.g., asthma or COPD).