allyl 2-((tert-butyl(1-(diethoxyphosphoryl)-2,2-dimethylpropyl)amino)oxy)-2-methylpropanoate | 1393670-68-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: allyl 2-((tert-butyl(1-(diethoxyphosphoryl)-2,2-dimethylpropyl)amino)oxy)-2-methylpropanoate
• 英文别名: Prop-2-enyl 2-[tert-butyl-(1-diethoxyphosphoryl-2,2-dimethylpropyl)amino]oxy-2-methylpropanoate；prop-2-enyl 2-[tert-butyl-(1-diethoxyphosphoryl-2,2-dimethylpropyl)amino]oxy-2-methylpropanoate
• CAS: 1393670-68-2
• 化学式: C₂₀H₄₀NO₆P
• 分子量: 421.514
• InChiKey: HGXIAXHOXFVTIS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  28
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  74.3
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  allyl 2-((tert-butyl(1-(diethoxyphosphoryl)-2,2-dimethylpropyl)amino)oxy)-2-methylpropanoate 以 叔丁醇 为溶剂， 反应 48.0h， 生成 diethyl (1-((((allyloxy)carbonyl)oxy)(tert-butyl)amino)-2,2-dimethylpropyl)phosphonate
  参考文献：
  名称：

  Direct functionalization of labile alkoxyamines

  摘要：

  Direct esterification of a labile alkoxyamine (RRNOR3)-R-1-N-2, which was previously reported as unsuccessful, is achieved by a Mitsunobu reaction or a nucleophilic substitution. Ester derivatives are obtained under smooth conditions and easily purified. Macrocyclization attempts on ester derivatives were successful for five-membered ring lactones and unsuccessful for 13-membered ring lactones. Moreover, the success of the cyclization was dramatically dependent on the quality of the solution degassing. Poor degassing led to unexpected carbonate alkoxyamine. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.06.049
• 作为产物：
  描述：

  3-溴丙烯 、 N-(2-methyl-2-propyl)-N-(1-diethylphosphono-2,2-dimethylpropyl)-O-(2-carboxyprop-2-yl)hydroxylamide 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 苯 为溶剂， 反应 24.0h， 以57%的产率得到allyl 2-((tert-butyl(1-(diethoxyphosphoryl)-2,2-dimethylpropyl)amino)oxy)-2-methylpropanoate
  参考文献：
  名称：

  Direct functionalization of labile alkoxyamines

  摘要：

  Direct esterification of a labile alkoxyamine (RRNOR3)-R-1-N-2, which was previously reported as unsuccessful, is achieved by a Mitsunobu reaction or a nucleophilic substitution. Ester derivatives are obtained under smooth conditions and easily purified. Macrocyclization attempts on ester derivatives were successful for five-membered ring lactones and unsuccessful for 13-membered ring lactones. Moreover, the success of the cyclization was dramatically dependent on the quality of the solution degassing. Poor degassing led to unexpected carbonate alkoxyamine. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.06.049

文献信息

• Alkoxyamines originating from $g(b)-phoshorylated nitroxides and use thereof in radical polymerisation
  申请人：Couturier Luc Jean

  公开号：US20060142511A1

  公开（公告）日：2006-06-29

  A subject-matter of the invention is alkoxyamines resulting from β-phosphorated nitroxides corresponding to the formula: These compounds can be used as initiators for the (co)polymerizations of at least one monomer which can be polymerized by the radical route.

  本发明的一个主题是由式中β-磷化亚硝基产生的烷氧基胺： 这些化合物可用作至少一种可通过自由基途径聚合的单体的（共）聚合引发剂。
• US7772340B2
  申请人：——

  公开号：US7772340B2

  公开（公告）日：2010-08-10