7-[3-[[N'-[N'-[6-[[amino-[[amino-[[1-(6-carboxy-8-ethyl-3-fluoro-5-oxo-1,8-naphthyridin-2-yl)pyrrolidin-3-yl]-methylamino]methylidene]amino]methylidene]amino]hexyl]carbamimidoyl]carbamimidoyl]-methylamino]pyrrolidin-1-yl]-1-ethyl-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 7-[3-[[N'-[N'-[6-[[amino-[[amino-[[1-(6-carboxy-8-ethyl-3-fluoro-5-oxo-1,8-naphthyridin-2-yl)pyrrolidin-3-yl]-methylamino]methylidene]amino]methylidene]amino]hexyl]carbamimidoyl]carbamimidoyl]-methylamino]pyrrolidin-1-yl]-1-ethyl-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid
• 化学式: C₄₂H₅₆F₂N₁₆O₆
• 分子量: 919.0
• InChiKey: DDBKRPHSCDTSIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  66
• 可旋转键数：
  19
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  308
• 氢给体数：
  6
• 氢受体数：
  16

文献信息

• ANTIVIRAL AND ANTIMICROBIAL COMPOUNDS
  申请人：Vymed Corporation

  公开号：US20140073631A1

  公开（公告）日：2014-03-13

  Disclosed are guanidine and biguanidine derivatives which have anti-viral and antibacterial activity. Also disclosed are pharmaceutical compositions containing such compounds as an active ingredient, and anti-viral and anti-bacterial methods utilizing such compounds. Methods of treating infections using the guanidine and biguanidine derivatives are also disclosed.

  本文披露了具有抗病毒和抗菌活性的胍和双胍衍生物。还披露了含有这些化合物作为活性成分的药物组合物，以及利用这些化合物的抗病毒和抗菌方法。还披露了使用胍和双胍衍生物治疗感染的方法。