[2-(Boranuidyl-tert-butyl-methylphosphaniumyl)ethyl-tert-butyl-methylphosphaniumyl]boranuide

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 英文名称: [2-(Boranuidyl-tert-butyl-methylphosphaniumyl)ethyl-tert-butyl-methylphosphaniumyl]boranuide
• 英文别名: [2-(boranuidyl-tert-butyl-methylphosphaniumyl)ethyl-tert-butyl-methylphosphaniumyl]boranuide
• 化学式: C₁₂H₃₄B₂P₂
• 分子量: 261.971
• InChiKey: IGXXXTFYVJAGJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.44
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,2-bis(5-hydroxy-3-oxa-1-pentyloxy)benzene ditosylate 、 [2-(Boranuidyl-tert-butyl-methylphosphaniumyl)ethyl-tert-butyl-methylphosphaniumyl]boranuide 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 1.0h， 以42%的产率得到(11-boranuidyl-8,11-ditert-butyl-2,5,14,17-tetraoxa-8,11-diphosphoniabicyclo[16.4.0]docosa-1(22),18,20-trien-8-yl)boranuide
  参考文献：
  名称：

  Synthesis of Enantiopure P-Stereogenic Diphosphacrowns using P-Stereogenic Secondary Phosphines

  摘要：

  A new synthetic route to enantiopure P-stereogenic benzodiphosphacrowns using a P-stereogenic secondary bisphosphine as the key building block is reported. Syntheses of the enantiomer and P-stereogenic crowns with various ring structures, as well as deboranation of the crown compounds and subsequent reaction with a platinum complex, are described.

  DOI：

  10.1021/jo302748x
• 作为产物：
  描述：

  (R)-叔丁基(羟甲基)甲基膦硼烷 在 dipotassium peroxodisulfate 、 四甲基乙二胺 、 ruthenium(III) chloride trihydrate 、 水 、 仲丁基锂 、 potassium hydroxide 作用下， 以 四氢呋喃 、 正己烷 、 环己烷 、 丙酮 为溶剂， 反应 3.0h， 生成 [2-(Boranuidyl-tert-butyl-methylphosphaniumyl)ethyl-tert-butyl-methylphosphaniumyl]boranuide
  参考文献：
  名称：

  Synthesis of Enantiopure P-Stereogenic Diphosphacrowns using P-Stereogenic Secondary Phosphines

  摘要：

  A new synthetic route to enantiopure P-stereogenic benzodiphosphacrowns using a P-stereogenic secondary bisphosphine as the key building block is reported. Syntheses of the enantiomer and P-stereogenic crowns with various ring structures, as well as deboranation of the crown compounds and subsequent reaction with a platinum complex, are described.

  DOI：

  10.1021/jo302748x

文献信息

• Stereospecific Construction of a <i>trans</i>-1,4-Diphosphacyclohexane Skeleton
  作者：Yasuhiro Morisaki、Hiroaki Imoto、Yuko Ouchi、Yuuya Nagata、Yoshiki Chujo

  DOI：10.1021/ol800261j

  日期：2008.4.1

  trans-1,4-Diphosphacyclohexanes were successfully synthesized by the stereospecific intramolecular coupling reaction of the optically active bisphosphine. This is a new route for the construction of the trans-1,4-diphosphacyclohexane skeleton. A cis isomer was also prepared along with the trans isomer from a mixture of rac- and meso-bisphosphines. The coordinated boranes were easily removed to afford

  通过旋光性双膦的立体定向分子内偶联反应成功合成了反式1,4-二磷酸环己烷。这是构建反式1，4-二磷酸环己烷骨架的新途径。还从外消旋和内消旋双膦的混合物中制备了顺式异构体和反式异构体。容易除去配位的硼烷，得到相应的1，4-二磷酸环己烷。
• Catalytic Asymmetric Deprotonation Using a Ligand Exchange Approach
  作者：Matthew J. McGrath、Peter O'Brien

  DOI：10.1021/ja056026d

  日期：2005.11.30

  A novel ligand exchange approach to catalytic asymmetric deprotonation-electrophilic trapping has been developed that uses 1.3 equiv of s-BuLi, 0.06-0.2 equiv of chiral diamine ((-)-sparteine or a (+)-sparteine surrogate), and 1.2 equiv of achiral bispidine. The methodology is illustrated with a range of examples and gives access to either enantiomer of useful chiral products in good yields using substoichiometric amounts of chiral diamines.