2-(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)dipyrido[3,2-a:2',3'-c]quinoxaline | 1236042-47-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 菲咯啉
• 英文名称: 2-(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)dipyrido[3,2-a:2',3'-c]quinoxaline
• CAS: 1236042-47-9
• 化学式: C₂₂H₂₂N₅O
• 分子量: 372.45
• InChiKey: AMKZFKRCXZYAGZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  28
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  、 5,6-二氨基-1,10-邻菲罗啉 以 乙醇 为溶剂， 反应 4.0h， 以70%的产率得到2-(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)dipyrido[3,2-a:2',3'-c]quinoxaline
  参考文献：
  名称：

  Synthesis of redox sensitive dyes based on a combination of long wavelength emitting fluorophores and nitroxides

  摘要：

  New, nitroxide-fluorophore acceptor-donor compounds were synthesized based on long wavelength (570-790 nm) emitting 9-diethylamino-5H-benzo[a]phenoxazin-5-one, 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene and metal-ligand complex fluorophores. The fluorophores and nitroxides were linked via a robust C=C bond. The steady-state spectral properties of the new donor-acceptor compounds and their diamagnetic (sterically hindered amine) derivatives were studied. Titration of nitroxides with ascorbic acid sodium salt to diamagnetic N-hydroxy compounds resulted in fluorescence enhancement The Ru-complex modified with nitroxide exhibited fluorescence increase and electron paramagnetic resonance band broadening upon B-deoxyribonucleic acid addition providing evidence of binding with B-deoxyribonucleic acid. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.dyepig.2010.03.030

文献信息

• Synthesis of redox sensitive dyes based on a combination of long wavelength emitting fluorophores and nitroxides
  作者：Balázs Bognár、József Jekő、Tamás Kálai、Kálmán Hideg

  DOI：10.1016/j.dyepig.2010.03.030

  日期：2010.11

  New, nitroxide-fluorophore acceptor-donor compounds were synthesized based on long wavelength (570-790 nm) emitting 9-diethylamino-5H-benzo[a]phenoxazin-5-one, 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene and metal-ligand complex fluorophores. The fluorophores and nitroxides were linked via a robust C=C bond. The steady-state spectral properties of the new donor-acceptor compounds and their diamagnetic (sterically hindered amine) derivatives were studied. Titration of nitroxides with ascorbic acid sodium salt to diamagnetic N-hydroxy compounds resulted in fluorescence enhancement The Ru-complex modified with nitroxide exhibited fluorescence increase and electron paramagnetic resonance band broadening upon B-deoxyribonucleic acid addition providing evidence of binding with B-deoxyribonucleic acid. (C) 2010 Elsevier Ltd. All rights reserved.