(S,S)-isopropylbis[2-(1-N,N-dimethylaminoethyl)phenyl]phosphine | 186047-43-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (S,S)-isopropylbis[2-(1-N,N-dimethylaminoethyl)phenyl]phosphine
• 英文别名: (1S)-1-[2-[[2-[(1S)-1-(dimethylamino)ethyl]phenyl]-propan-2-ylphosphanyl]phenyl]-N,N-dimethylethanamine
• CAS: 186047-43-8
• 化学式: C₂₃H₃₅N₂P
• 分子量: 370.518
• InChiKey: PQLJFIIIEAEIOZ-OALUTQOASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (S,S)-isopropylbis[2-(1-N,N-dimethylaminoethyl)phenyl]phosphine 、 bis(norbornadiene)rhodium(l)tetrafluoroborate 生成
  参考文献：
  名称：

  Yamada, Issaku; Ohkouchi, Munetaka; Yamaguchi, Motowo, Journal of the Chemical Society. Perkin transactions I, 1997, # 12, p. 1869 - 1873

  摘要：

  DOI：
• 作为产物：
  描述：

  二氯异丙基膦 、 (S)-(-)-N,N-二甲基-1-苯乙胺 在 正丁基锂 作用下， 以 乙醚 、 正己烷 为溶剂， 以32%的产率得到(S,S)-isopropylbis[2-(1-N,N-dimethylaminoethyl)phenyl]phosphine
  参考文献：
  名称：

  Yamada, Issaku; Ohkouchi, Munetaka; Yamaguchi, Motowo, Journal of the Chemical Society. Perkin transactions I, 1997, # 12, p. 1869 - 1873

  摘要：

  DOI：

文献信息

• Homogeneous asymmetric hydrogenation catalyst
  申请人：Shimizu Hideo

  公开号：US20090203927A1

  公开（公告）日：2009-08-13

  Provide that a useful catalyst for homogeneous hydrogenation, particularly a catalyst for homogeneous asymmetric hydrogenation for hydrogenation, particularly asymmetric hydrogenation, which is obtainable with comparative ease and is excellent in economically and workability, and a process for producing a hydrogenated compound of an unsaturated compound, particularly an optically active compound using said catalyst with a high yield and optical purity.

  提供一种用于均相氢化的有用催化剂，特别是用于均相不对称氢化的催化剂，特别是不对称氢化的催化剂，该催化剂易于获得，在经济性和可操作性方面表现出色，以及一种使用该催化剂产生不饱和化合物的氢化物的方法，特别是使用高产率和光学纯度的该催化剂产生手性活性化合物。
• HOMOGENEOUS ASYMMETRIC HYDROGENATION CATALYST
  申请人：SHIMIZU Hideo

  公开号：US20110065929A1

  公开（公告）日：2011-03-17

  Provide that a useful catalyst for homogeneous hydrogenation, particularly a catalyst for homogeneous asymmetric hydrogenation for hydrogenation, particularly asymmetric hydrogenation, which is obtainable with comparative ease and is excellent in economically and workability, and a process for producing a hydrogenated compound of an unsaturated compound, particularly an optically active compound using said catalyst with a high yield and optical purity.

  提供一种有用的均相加氢催化剂，特别是一种用于均相不对称加氢的催化剂，特别是不对称加氢，该催化剂可以相对容易地获得，并且在经济性和可操作性方面表现出色。同时提供一种使用该催化剂高产率和光学纯度地制备不饱和化合物的氢化物，特别是光学活性化合物的方法。
• Homogeneous Asymmetric Hydrogenation Process
  申请人：SHIMIZU Hideo

  公开号：US20100137615A1

  公开（公告）日：2010-06-03

  Provide that a useful catalyst for homogeneous hydrogenation, particularly a catalyst for homogeneous asymmetric hydrogenation for hydrogenation, particularly asymmetric hydrogenation, which is obtainable with comparative ease and is excellent in economically and workability, and a process for producing a hydrogenated compound of an unsaturated compound, particularly an optically active compound using said catalyst with a high yield and optical purity.

  提供一种有用的均相氢化催化剂，特别是一种用于不对称氢化反应的均相催化剂，该催化剂易于获得，经济实用，易于操作，并且使用该催化剂可以高产率、高光学纯度地制备不饱和化合物的氢化产物，特别是光学活性化合物的氢化产物。
• A novel chiral phosphinediamine ligand and asymmetric hydrogenation of acrylic acid derivatives
  作者：Issaku Yamada、Motowo Yamaguchi、Takamichi Yamagishi

  DOI：10.1016/s0957-4166(96)00437-5

  日期：1996.12

  A novel chiral phosphinediamine ligand (PN2) was prepared from (S)-1-phenylethylamine and dichloroisopropylphosphine. The rhodium-PN2 catalyst utilizing selective ligation of the amino unit and electrostatic interaction between the ligand and a substrate gave high enantioselectivities up to 92% ee in asymmetric hydrogenations of acrylic acid derivatives. Copyright (C) 1996 Elsevier Science Ltd
• US7902110B2
  申请人：——

  公开号：US7902110B2

  公开（公告）日：2011-03-08