ethyl (2R,4S)-4-[[2-amino-1-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxyiminoethyl]amino]-2-ethyl-6-methoxy-3,4-dihydro-2H-1,5-naphthyridine-1-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: ethyl (2R,4S)-4-[[2-amino-1-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxyiminoethyl]amino]-2-ethyl-6-methoxy-3,4-dihydro-2H-1,5-naphthyridine-1-carboxylate
• 化学式: C₂₄H₂₇F₆N₅O₄
• 分子量: 563.5
• InChiKey: FSNPSRZNNWLUFR-IEAUQHRDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  39
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  122
• 氢给体数：
  3
• 氢受体数：
  13

文献信息

• TETRAHYDRONAPHTHYRIDINE DERIVATIVES AS CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP1732924A2

  公开（公告）日：2006-12-20
• US7781443B2
  申请人：——

  公开号：US7781443B2

  公开（公告）日：2010-08-24
• [EN] TETRAHYDRONAPHTHYRIDINE DERIVATIVES AND A PROCESS FOR PREPARING THE SAME<br/>[FR] DERIVES DE TETRAHYDRONAPHTYRIDINE ET PROCEDE D'ELABORATION DESDITS DERIVES
  申请人：TANABE SEIYAKU CO

  公开号：WO2005095395A2

  公开（公告）日：2005-10-13

  A novel compound of the formula (I): wherein R1 is alkoxycarbonyl or the like, R2 is alkyl or the like; R3 is hydrogen or the like; R4 is alkylene or the like; R5 is optionally substituted heterocyclic group; R6, R7, and R8 are independently hydrogen; alkyl, alkoxy, or the like; R10 is optionally substituted aromatic ring, or the like; or a pharmaceutically acceptable salt thereof, which has an inhibitory activity against cholesteryl ester transfer protein (CETP).