3-(4-Bromophenyl)-2-[3-[2-(dimethylamino)ethenyl]-4-nitrophenyl]quinazolin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-(4-Bromophenyl)-2-[3-[2-(dimethylamino)ethenyl]-4-nitrophenyl]quinazolin-4-one
• 英文别名: 3-(4-bromophenyl)-2-[3-[2-(dimethylamino)ethenyl]-4-nitrophenyl]quinazolin-4-one
• 化学式: C24H19BrN4O3
• 分子量: 491.3
• InChiKey: ZDCOLCHXZBVSAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  81.7
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• COMPOUNDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASE
  申请人：Hansen Henrik C.

  公开号：US20110294807A1

  公开（公告）日：2011-12-01

  Disclosed are novel compounds that are useful for regulating the expression of apolipoprotein A-I (ApoA-I), and their use for the treatment and prevention of cardiovascular disease and related disease states, including cholesterol- or lipid-related disorders, such as, for example, atherosclerosis. Also disclosed are pharmaceutical compositions comprising the novel compounds. Formula (I)

  本发明揭示了一种新型化合物，可用于调节载脂蛋白A-I（ApoA-I）的表达，并且其用于治疗和预防心血管疾病和相关疾病状态，包括胆固醇或脂质相关疾病，例如动脉粥样硬化。还揭示了包含这种新型化合物的药物组合物。公式（I）
• Compounds for the prevention and treatment of cardiovascular disease
  申请人：RESVERLOGIX CORP.

  公开号：EP2660238A1

  公开（公告）日：2013-11-06

  Disclosed are novel compounds that are useful for regulating the expression of apolipoprotein A-I (ApoA-I), and their use for the treatment and prevention of cardiovascular disease and related disease states, including cholesterol- or lipid-related disorders, such as, for example, atherosclerosis. Also disclosed are pharmaceutical compositions comprising the novel compounds.

  所公开的新型化合物可用于调节载脂蛋白 A-I（ApoA-I）的表达，并可用于治疗和预防心血管疾病及相关疾病状态，包括胆固醇或脂质相关疾病，如动脉粥样硬化等。还公开了包含这些新型化合物的药物组合物。
• US8952021B2
  申请人：——

  公开号：US8952021B2

  公开（公告）日：2015-02-10