AMTCh | 24857-13-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: AMTCh
• 英文别名: acetyl-β-methylthiocholine；Acetyl-beta-methylthiocholine；2-acetylsulfanylpropyl(trimethyl)azanium
• CAS: 24857-13-4
• 化学式: C₈H₁₈NOS
• 分子量: 176.303
• InChiKey: SHEXQJZFGTZWSV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Carbamate analogs of thiaphysovenine, pharmaceutical compositions, and method for inhibiting cholinesterases
  申请人：The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services

  公开号：EP1251131A2

  公开（公告）日：2002-10-23

  This invention relates to certain carbamate analogs of thiaphysovenine of the formula    wherein R1 is H and R2 is C4 - C10 alkyl; R1 and R2 are independently C1 -C10 alkyl; or R1 is H and R2 is a group of the formula wherein R3 is H and R4 is an isopropyl group; including optical isomers of the 3aS series, racemic compounds of this type and processes for their preparation. Pharmaceutical compositions containing such compounds are also provided. Such compounds and compositions are useful as cholinesterase inhibitors, especially butyrylcholinesterase inhibitors.

  本发明涉及某些氨基甲酸酯类似物，其式为 式中 R1 是 H，R2 是 C4 - C10 烷基； R1 和 R2 独立地为 C1 -C10 烷基；或 R1 是 H，R2 是式中的基团 其中 R3 是 H，R4 是异丙基； 包括 3aS 系列的光学异构体、 此类外消旋化合物及其制备工艺。此外，还提供了含有此类化合物的药物组合物。此类化合物和组合物可用作胆碱酯酶抑制剂，特别是丁酰基胆碱酯酶抑制剂。
• BIO-ELECTRODE COMPOSITION, BIO-ELECTRODE, METHOD FOR MANUFACTURING BIOELECTRODE, AND REACTION COMPOSITE
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP3995548A1

  公开（公告）日：2022-05-11

  A bio-electrode composition contains (A) a reaction composite of an ionic polymer material and a carbon particle. The component (A) contains the carbon particle bonding to the polymer containing a repeating unit having a structure selected from the group consisting of salts of ammonium, lithium, sodium, potassium, and silver formed with any of fluorosulfonic acid, fluorosulfonimide, and N-carbonyl-fluorosulfonamide. Thus, the present invention provides: a bio-electrode composition capable of forming a living body contact layer for a bio-electrode which is excellent in electric conductivity and biocompatibility, light-weight, and manufacturable at low cost, and which prevents significant reduction in the electric conductivity even when wetted with water or dried; a bio-electrode including a living body contact layer formed of the bio-electrode composition; and a method for manufacturing the bio-electrode.

  一种生物电极组合物包含（A）离子聚合物材料和碳颗粒的反应复合材料。组分（A）包含碳颗粒，碳颗粒与聚合物结合，聚合物含有重复单元，该重复单元的结构选自由铵盐、锂盐、钠盐、钾盐和银盐组成的组，这些盐与氟磺酸、氟磺酰亚胺和 N-羰基-氟磺酰胺中的任意一种形成。因此，本发明提供了：一种能够为生物电极形成活体接触层的生物电极组合物，其导电性和生物相容性极佳，重量轻，可低成本制造，即使被水浸湿或干燥，也不会显著降低导电性；一种生物电极，包括由该生物电极组合物形成的活体接触层；以及一种制造该生物电极的方法。
• CARBAMATE ANALOGS OF THIAPHYSOVENINE, PHARMACEUTICAL COMPOSITIONS, AND METHOD FOR INHIBITING CHOLINESTERASES
  申请人：THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY of the DEPARTMENT OF HEALTH AND HUMAN SERVICES

  公开号：EP0605474B1

  公开（公告）日：2003-11-26
• SUBSTITUTED PHENSERINES AND PHENYLCARBAMATES OF (-)-ESEROLINE, (-)-N1-NORESEROLINE, AND (-)-N1-BENZYLNORESEROLINE; AS SPECIFIC INHIBITORS OF ACETYLCHOLINESTERASE
  申请人：THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY of the DEPARTMENT OF HEALTH AND HUMAN SERVICES

  公开号：EP0606366B1

  公开（公告）日：2003-06-04
• SULFONYL FLUORIDES FOR THE TREATMENT OF ALZHEIMER'S DISEASE
  申请人：The Board of Regents, The University of Texas System

  公开号：EP0921790B1

  公开（公告）日：2004-05-19