6-环氧氯丙烷强力霉素 | 3219-99-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 四环素类
• 中文名称: 6-环氧氯丙烷强力霉素
• 中文别名: 6-表强力霉素；6-差向多西环素
• 英文名称: doxycyline
• 英文别名: 6-epidoxycycline；(4aR)-4c-dimethylamino-3,5c,10,12,12a-pentahydroxy-6t-methyl-1,11-dioxo-(4ar,5ac,12ac)-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide；(4aR)-4c-Dimethylamino-3,5c,10,12,12a-pentahydroxy-6t-methyl-1,11-dioxo-(4ar,5ac,12ac)-1,4,4a,5,5a,6,11,12a-octahydro-naphthacen-2-carbonsaeure-amid
• CAS: 3219-99-6
• 化学式: C₂₂H₂₄N₂O₈
• 分子量: 444.441
• InChiKey: JBIWCJUYHHGXTC-IPJAVASBSA-N

物化性质

• 熔点：
  >200°C (dec.)
• 沸点：
  762.6±60.0 °C(Predicted)
• 密度：
  1.63±0.1 g/cm3(Predicted)
• 溶解度：
  少许溶于甲醇

计算性质

• 辛醇/水分配系数(LogP)：
  -0.35
• 重原子数：
  32.0
• 可旋转键数：
  2.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  181.62
• 氢给体数：
  6.0
• 氢受体数：
  9.0

安全信息

• WGK Germany：
  3

反应信息

• 作为产物：
  描述：

  盐酸甲烯土霉素 在 closo-3,3-(η²,η³-C7H7CH2)-3,1,2-RhC2B9H11 氢气 作用下， 以 甲醇 为溶剂， 43.0 ℃ 、10.13 MPa 条件下， 反应 4.0h， 以2%的产率得到6-环氧氯丙烷强力霉素
  参考文献：
  名称：

  Stereoselective hydrogenation of methacycline to Doxycycline catalysed by rhodium-carborane complexes

  摘要：

  Doxycycline (2), a tetracycline antibiotic extensively used in chemotherapy, was obtained stereoselectively from the hydrogenation of methacycline (1), catalysed by novel rhodium-carborane complexes.

  DOI：

  10.1016/s0040-4039(00)60321-0

文献信息

• [EN] SALTS OF TETRACYCLINES<br/>[FR] SELS DE TÉTRACYCLINES
  申请人：HOVIONE SCIENTIA LTD

  公开号：WO2017089809A1

  公开（公告）日：2017-06-01

  A tetracycline salt comprising a tetracycline and an organic acid wherein the organic acid is oxalic acid or maleic acid is provided. The tetracycline is preferably doxycycline, minocycline, sancycline, lymecycline, tetracycline or demeclocycline, and preferred salts include oxycycline maleate, minocycline oxalate, tetracycline oxalate, demeclocycline maleate, demeclocycline oxalate, sancycline maleate, lymecycline maleate, or lymecycline oxalate. A pharmaceutical formulation comprising a tetracycline salt according to the invention is also provided, as is a medical device having coated thereon a salt or pharmaceutical formulation according to the invention.A salt of the invention, or a formulation of the invention are also provided for use as medicaments, particularly for use in the treatment or prevention of an inflammation and/or an infection. There is also provided a method of preparing a tetracycline salt, which method comprises reacting a tetracycline base with an excess of an organic acid in a solvent.

  提供一种四环素盐，包括四环素和有机酸，其中有机酸是草酸或马来酸。四环素首选为多西环素、米诺环素、桑环素、利美环素、四环素或地美环素，首选盐包括草环素马来酸盐、米诺环素草酸盐、四环素草酸盐、地美环素马来酸盐、地美环素草酸盐、桑环素马来酸盐、利美环素马来酸盐或利美环素草酸盐。还提供了一种包括根据本发明的四环素盐的药物配方，以及涂有根据本发明的盐或药物配方的医疗器械。本发明还提供了一种用作药物的本发明的盐或配方，特别用于治疗或预防炎症和/或感染。还提供了一种制备四环素盐的方法，该方法包括在溶剂中将四环素碱与过量的有机酸反应。
• TETRACYCLINE COMPOUNDS HAVING TARGET THERAPEUTIC ACTIVITIES
  申请人：Paratek Pharmaceuticals, Inc.

  公开号：US20180016225A1

  公开（公告）日：2018-01-18

  Methods and compounds for treating diseases with tetracycline compounds having a target therapeutic activity are described.

  使用具有目标治疗活性的四环素化合物治疗疾病的方法和化合物被描述。
• Methods of Using Substituted Tetracycline Compounds to Modulate RNA
  申请人：Levy Stuart B.

  公开号：US20120245130A1

  公开（公告）日：2012-09-27

  A method for modulating RNA with tetracycline compounds is described.

  本文描述了一种使用四环素化合物调节RNA的方法。
• SubstitutedTetracycline Compounds for the Treatment of Malaria
  申请人：DRAPER Michael

  公开号：US20120101071A1

  公开（公告）日：2012-04-26

  This invention provides a method for treating or preventing malaria in a subject. The method includes administering to the subject an effective amount of a substituted tetracycline compound, such that malaria is treated or prevented. In one aspect, the invention relates to pharmaceutical compositions which include an effective amount of a tetracycline compound to treat malaria in a subject and a pharmaceutically acceptable carrier. The substituted tetracycline compounds of the invention can be used to in combination with one or more anti-malarial compounds or can be used to treat or prevent malaria which is resistant to one or more other anti-malarial compounds.

  本发明提供了一种治疗或预防疟疾的方法。该方法包括向受试者施用足够量的取代四环素化合物，以治疗或预防疟疾。在一方面，本发明涉及制药组合物，其包括足够量的四环素化合物以治疗受试者的疟疾和药学上可接受的载体。本发明的取代四环素化合物可以与一种或多种抗疟疾化合物结合使用，或者可以用于治疗或预防对一种或多种其他抗疟疾化合物产生耐药性的疟疾。
• Salts of tetracyclines
  申请人：Hovione Scientia Limited

  公开号：US10543298B2

  公开（公告）日：2020-01-28

  A tetracycline salt comprising a tetracycline and an organic acid wherein the organic acid is oxalic acid or maleic acid is provided. The tetracycline is preferably doxycycline, minocycline, sancycline, lymecycline, tetracycline or demeclocycline, and preferred salts include oxycycline maleate, minocycline oxalate, tetracycline oxalate, demeclocycline maleate, demeclocycline oxalate, sancycline maleate, lymecycline maleate, or lymecycline oxalate. A pharmaceutical formulation comprising a tetracycline salt according to the invention is also provided, as is a medical device having coated thereon a salt or pharmaceutical formulation according to the invention. A salt of the invention, or a formulation of the invention are also provided for use as medicaments, particularly for use in the treatment or prevention of an inflammation and/or an infection. There is also provided a method of preparing a tetracycline salt, which method comprises reacting a tetracycline base with an excess of an organic acid in a solvent.

  提供了一种由四环素和有机酸组成的四环素盐，其中有机酸为草酸或马来酸。四环素最好是多西环素、米诺环素、山西环素、莱美环素、四环素或地美环素，优选的盐包括马来酸氧环素、草酸米诺环素、草酸四环素、马来酸地美环素、草酸地美环素、马来酸山西环素、马来酸莱美环素或草酸莱美环素。此外，还提供了一种包含根据本发明的四环素盐的药物制剂，以及一种涂有根据本发明的盐或药物制剂的医疗器械。本发明的盐或制剂还可用作药物，特别是用于治疗或预防炎症和/或感染。还提供了一种制备四环素盐的方法，该方法包括在溶剂中使四环素碱与过量的有机酸反应。