2-(3-hydroxy-propyl)-benzo[d]isothiazole-3-thione | 19148-70-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 2-(3-hydroxy-propyl)-benzo[d]isothiazole-3-thione
• 英文别名: 2-(3-Hydroxypropyl)-1,2-benzothiazole-3-thione
• CAS: 19148-70-0
• 化学式: C₁₀H₁₁NOS₂
• 分子量: 225.335
• InChiKey: IVCHTNYRVPKUHV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  80.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1,2-苯并二噻戊环-3-硫酮 、 3-氨基-1-丙醇 以 乙醇 为溶剂， 生成 2-(3-hydroxy-propyl)-benzo[d]isothiazole-3-thione
  参考文献：
  名称：

  Baruffini; Borgna; Gialdi, Farmaco, Edizione Scientifica, 1968, vol. 23, # 1, p. 3 - 15

  摘要：

  DOI：

文献信息

• Antimicrobial activity of N-hydroxyalkyl 1,2-benzisothiazol-3(2H) -ones and their thiono analogues
  作者：P Borgna、ML Carmellino、M Natangelo、G Pagani、F Pastoni、M Pregnolato、M Terreni

  DOI：10.1016/s0223-5234(97)89857-1

  日期：1996.1

  N-Hydroxyalkyl derivatives of 1,2-benzisothiazol-3(2H)-one and 1,2-benzisothiazol-3(2H)-thione have been prepared and their antifungal and antibacterial activity evaluated. Several compounds were active against selected fungi and Gram-positive microorganisms. Interesting activity was observed against the anaerobic strain Clostridium perfringens. Generally the more active compounds belong to the class of 1,2-benzisothiazol-3(2H)-ones. The retardation matches R(M) of the compounds was also evaluated but the results obtained show that lipophilicity has only a minor effect on the antimicrobial activity.
• Baruffini; Borgna; Gialdi, Farmaco, Edizione Scientifica, 1968, vol. 23, # 1, p. 3 - 15
  作者：Baruffini、Borgna、Gialdi、Ponci

  DOI：——

  日期：——