4-[(4-hydroxyphenyl)methyl]-3,5-heptanedione | 67206-04-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-[(4-hydroxyphenyl)methyl]-3,5-heptanedione
• 英文别名: 4-[(4-Hydroxyphenyl)methyl]heptane-3,5-dione
• CAS: 67206-04-6
• 化学式: C₁₄H₁₈O₃
• 分子量: 234.295
• InChiKey: MFFJEDKYVVWWID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3,5-庚烷二酮 生成 4-[(4-hydroxyphenyl)methyl]-3,5-heptanedione
  参考文献：
  名称：

  CARABATEAS, P. J.;DIANA, G. D.

  摘要：

  DOI：

文献信息

• 4-(Arylaliphatic)isoxazoles
  申请人：Sterling Drug Inc.

  公开号：US04268678A1

  公开（公告）日：1981-05-19

  4-(Arylaliphatic)isoxazoles, having antiviral activity, are prepared by reacting with hydroxylamine a diketone of the formula Ar-Y-CH(CO-R).sub.2, wherein Ar is substituted phenyl, Y is (CH.sub.2).sub.n or O(CH.sub.2).sub.n, and R is lower-alkyl.

  具有抗病毒活性的4-(芳基脂肪)异噁唑可通过将羟胺与化学式为Ar-Y-CH(CO-R).sub.2的二酮反应制备，其中Ar为取代苯基，Y为(CH.sub.2).sub.n或O(CH.sub.2).sub.n，而R为较低的烷基。
• Antiviral activity of some .beta.-diketones. 4. Benzyl diketones. In vitro activity against both RNA and DNA viruses
  作者：G. D. Diana、Philip M. Carabateas、Robert E. Johnson、Gordon L. Williams、Francis Pancic、Joseph C. Collins

  DOI：10.1021/jm00207a010

  日期：1978.9

  The synthesis and in vitro antiviral evaluation of a series of substituted benzyl beta-diketones are described. The introduction of a styryl group onto the phenyl ring enhanced activity against herpesvirus type 2. The 4-methoxystyryl homologue 8 was evaluated extensively in vitro and was found to be effective against both RNA and DNA viruses. Compound 8 was evaluated in the mouse vagina against herpes simplex type 1 and produced a significant increase in survival rate as well as in survival time.
• DIANA G. D.; CARABATEAS P. M.; JOHNSON R. E.; WILLIAMS G. L.; PANCIC F.; +, J. MED. CHEM., 1978, 21, NO 9, 889-894
  作者：DIANA G. D.、 CARABATEAS P. M.、 JOHNSON R. E.、 WILLIAMS G. L.、 PANCIC F.、 +

  DOI：——

  日期：——
• US4268678A
  申请人：——

  公开号：US4268678A

  公开（公告）日：1981-05-19