4-(6-Cyclohexyl-hexanoyl)-piperazine-1-carbonyl chloride | 479622-27-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-(6-Cyclohexyl-hexanoyl)-piperazine-1-carbonyl chloride
• 英文别名: 4-(6-Cyclohexylhexanoyl)piperazine-1-carbonyl chloride；4-(6-cyclohexylhexanoyl)piperazine-1-carbonyl chloride
• CAS: 479622-27-0
• 化学式: C₁₇H₂₉ClN₂O₂
• 分子量: 328.882
• InChiKey: AJDCDDYZUBAUAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(6-Cyclohexyl-hexanoyl)-piperazine-1-carbonyl chloride 在 palladium on activated charcoal 盐酸 、 4-二甲氨基吡啶 、 TEA 、 氢气 作用下， 以 1,4-二氧六环 、 N,N-二甲基甲酰胺 为溶剂， 生成 (2S,3R)-3-(1-Carbamimidoyl-piperidin-3-ylmethyl)-1-[4-(6-cyclohexyl-hexanoyl)-piperazine-1-carbonyl]-4-oxo-azetidine-2-carboxylic acid
  参考文献：
  名称：

  Synthesis of potent and highly selective inhibitors of human tryptase

  摘要：

  The serine protease tryptase has been implicated in allergic and inflammatory diseases and associated with asthma. The synthesis and SAR of a series of N1-activated-4-carboxy azetidinones are described, resulting in identification of BMS-363131 (2) as a potent inhibitor of human tryptase (IC50 < 1.7 nM) with high selectivity (>3000-fold) for tryptase versus related serine proteases including trypsin. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00689-3
• 作为产物：
  描述：

  4-(6-Cyclohexyl-hexanoyl)-piperazine-1-carboxylic acid tert-butyl ester 在 TEA 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 4-(6-Cyclohexyl-hexanoyl)-piperazine-1-carbonyl chloride
  参考文献：
  名称：

  Synthesis of potent and highly selective inhibitors of human tryptase

  摘要：

  The serine protease tryptase has been implicated in allergic and inflammatory diseases and associated with asthma. The synthesis and SAR of a series of N1-activated-4-carboxy azetidinones are described, resulting in identification of BMS-363131 (2) as a potent inhibitor of human tryptase (IC50 < 1.7 nM) with high selectivity (>3000-fold) for tryptase versus related serine proteases including trypsin. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00689-3

文献信息

• Synthesis of potent and highly selective inhibitors of human tryptase
  作者：William A. Slusarchyk、Scott A. Bolton、Karen S. Hartl、Ming-Hsing Huang、Glenn Jacobs、Wei Meng、Martin L. Ogletree、Zulan Pi、William A. Schumacher、Steven M. Seiler、James C. Sutton、Uwe Treuner、Robert Zahler、Guohua Zhao、Gregory S. Bisacchi

  DOI：10.1016/s0960-894x(02)00689-3

  日期：2002.11

  The serine protease tryptase has been implicated in allergic and inflammatory diseases and associated with asthma. The synthesis and SAR of a series of N1-activated-4-carboxy azetidinones are described, resulting in identification of BMS-363131 (2) as a potent inhibitor of human tryptase (IC50 < 1.7 nM) with high selectivity (>3000-fold) for tryptase versus related serine proteases including trypsin. (C) 2002 Elsevier Science Ltd. All rights reserved.