2-cyano-N-[(3,4-dihydroxyphenyl)methyl]-5-(4-hydroxy-3,5-dimethoxyphenyl)penta-2,4-dienamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-cyano-N-[(3,4-dihydroxyphenyl)methyl]-5-(4-hydroxy-3,5-dimethoxyphenyl)penta-2,4-dienamide
• 化学式: C₂₁H₂₀N₂O₆
• 分子量: 396.4
• InChiKey: PCJRDGRGEAYJJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  132
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• [EN] NOVEL COMPOUNDS FOR MODULATING CELL PROLIFERATION<br/>[FR] NOUVEAUX COMPOSES POUR LA MODULATION DE LA PROLIFERATION CELLULAIRE
  申请人：HSC RES DEV LP

  公开号：WO2005092904A1

  公开（公告）日：2005-10-06

  Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed.

  新型的苯乙烯丙烯腈化合物被揭示，这些化合物在治疗各种细胞增殖性疾病，如癌症方面具有用处。
• [EN] STYRYL ACRYLONITRILE COMPOUNDS AND THEIR USE TO PROMOTE MYELOPOIESIS<br/>[FR] COMPOSES STYRYL ACRYLONITRILE ET UTILISATION DESDITS COMPOSES POUR FAVORISER LA MYELOPOIESE
  申请人：HOSPITAL FOR SICK CHILDREN

  公开号：WO2003030895A1

  公开（公告）日：2003-04-17

  The invention relates to the use of organic compounds, styryl acrylonitrile compounds to promote myelopoiesis. These compounds thefore may be used to treat a subject suffering from neutropenia and other conditions which would benefit from increased myelopoieses. Moreover, the compounds may be used to treat hematopoietic cells ex-vivo to promote myelopoiesis and therefore may be used advantageously in bone marrow or peripheral blood stem cell transplant.

  本发明涉及使用有机化合物，即苯乙烯丙烯腈化合物，促进骨髓造血作用。因此，这些化合物可用于治疗患有中性粒细胞减少症和其他需要增加骨髓造血的病症的患者。此外，这些化合物可用于治疗体外的造血细胞以促进骨髓造血，因此可在骨髓或外周血干细胞移植中有优势应用。
• Styryl acrylonitrile compounds and their use to promote myelopoiesis
  申请人：Roifman Chaim

  公开号：US20050014690A1

  公开（公告）日：2005-01-20

  The invention relates to the use of organic compounds, styryl acrylonitrile compounds to promote myelopoiesis. These compounds thefore may be used to treat a subject suffering from neutropenia and other conditions which would benefit from increased myelopoieses. Moreover, the compounds may be used to treat hematopoietic cells ex-vivo to promote myelopoiesis and therefore may be used advantageously in bone marrow or peripheral blood stem cell transplant.

  本发明涉及使用有机化合物，即苯乙烯基丙烯腈化合物，以促进骨髓造血。这些化合物因此可以用于治疗患有中性粒细胞减少症和其他需要增强骨髓造血的状况的受试者。此外，这些化合物可以用于治疗体外的造血细胞，以促进骨髓造血，因此可以在骨髓或外周血干细胞移植中有优势使用。
• Inhibition of vascular endothelial growth factor
  申请人：Roifman M. Chaim

  公开号：US20060241084A1

  公开（公告）日：2006-10-26

  This invention relates to therapeutic organic compounds and inhibition of secretion of vascular endothelial growth factor (VEGF) and its effects, including angiogenesis.

  本发明涉及治疗有机化合物和抑制血管内皮生长因子（VEGF）分泌及其效应，包括血管生成。
• Novel Compounds for Modulating Cell Proliferation
  申请人：Roifman M. Chaim

  公开号：US20070243612A1

  公开（公告）日：2007-10-18

  Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed.

  本发明揭示了一种新型的苯乙烯腈化合物，可用于治疗多种细胞增殖性疾病，如癌症。